Aldo-keto reductases and toxicant metabolism
Aldo-keto reductases and toxicant metabolism
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DOI：
10.1021/bk-2003-0865
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发表时间：
2003-10
期刊：
影响因子：
--
通讯作者：
T. Penning;J. Petrash
中科院分区：
文献类型：
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作者：
T. Penning;J. Petrash
第1节：一般概述1.醛酮还原酶（AKR）超家族的介绍和概述第2节：AKRS和内源性毒素2.醛酮还原酶催化的与糖尿病并发症相关的内源性醛的解毒3.醛糖还原酶使脂质醛和它们的谷氨酸缀合物脱水4.醛糖还原酶在氧化磷脂脱乙酰化中的作用第3节：AKRS和外源性毒物：烟草相关致癌物5.还原酶在烟草特异性亚硝胺酮NNK 6脱乙酰化中的竞争作用。醛酮还原酶和多环芳烃的代谢活化7.小鼠二氢二醇脱氢酶的分子克隆与鉴定8致癌多环芳烃活性代谢物的高效合成9.由PAH活化的AKR途径产生的PAH邻醌的化学10.乙烯基-2 '-脱氧鸟苷加合物作为AKR介导的氧化应激剂量计的分析第4节：AKRS和外源性毒素：真菌毒素，醛和酮11.黄曲霉毒素醛还原酶12.黄曲霉毒素B1-二醛的竞争反应：酶促还原与赖氨酸加成13。使用哺乳动物细胞系研究醛酮还原酶在醛和酮解毒中的作用第5节：AKRS，应激反应和细胞信号传导14. 15.第15章.醛糖还原酶调节活性氧介导的炎症信号16.芽殖酵母Saccharomycescerevisiae胁迫反应中的醛酮还原酶
SECTION 1: GENERAL OVERVIEW 1. Introduction and Overview of the Aldo-Keto Reductase (AKR) Superfamily SECTION 2: AKRS AND ENDOGENOUS TOXICANTS 2. Aldo-Keto Reductase-Catalyzed Detoxication of Endogenous Aldehydes Associated With Diabetic Complications 3. Aldose Reductase Detoxifies Lipid Aldehydes and Their Glutathione Conjugates 4. Role of Aldose Reductase in the Detoxification of Oxidized Phospholipids SECTION 3: AKRS AND EXOGENOUS TOXICANTS: TOBACCO RELATED CARCINOGENS 5. Competing Roles of Reductases in the Detoxification of the Tobacco-Specific Nitrosamine Ketone NNK 6. Aldo-Keto Reductases and the Metabolic Activation of Polycyclic Aromatic Hydrocarbons 7. Molecular Cloning and Characterization of Dihydrodiol Dehydrogenase from Mouse 8 Efficient Synthesis of the Active Metabolites of Carcinogenic Polycyclic Aromatic Hydrocarbons 9. Chemistry of PAH o-Quinones Generated by the AKR Pathway of PAH Activation 10. Analysis of Etheno-2'-Deoxyguanosine Adducts as Dosimeters of AKR Mediated Oxidative Stress SECTION 4: AKRS AND EXOGENOUS TOXICANTS: MYCOTOXINS, ALDEHYDES AND KETONES 11. Aflatoxin Aldehyde Reductases 12. Competing Reactions of Aflatoxin B1-Dialdehyde: Enzymatic Reduction vs Adduction with Lysine 13. The use of mammalian cell lines to investigate the role of aldo-keto reductases in the detoxication of aldehydes and ketones SECTION 5: AKRS, THE STRESS RESPONSE AND CELL SIGNALING 14. Aldose Reductase and the Stress Response 15. Aldose Reductase Regulates Reactive Oxygen Species Mediated-Inflammatory Signals 16. Aldo-Keto Reductases in the Stress Response of the Budding Yeast Saccharomyces cerevisiae