The 'apparent' hydrolysis of alkyl esters during electrospray ionization
The 'apparent' hydrolysis of alkyl esters during electrospray ionization
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DOI：
10.1002/rcm.1104
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发表时间：
2003-01-01
影响因子：
2
通讯作者：
Cushman, M
中科院分区：
文献类型：
--
作者：
Silvestri, MA;Miles, D;Cushman, M
Electrospray ionization (ESI) mass spectrometry was employed to obtain both molecular weight confirmation and structural information for a series of novel alkenyldiarylmethane (ADAM) analogs. The mass spectral data were intended for use during the structure elucidation of ester hydrolysis products formed during an in vitro metabolism study of a series of novel ADAM analogs. The data on the precursor molecules show the presence of the molecular ion peak, [M+H](+), as well as a peak consistent with the hydrolysis product of the original ester ([MH-ROH+H2O](+)). However, chemical ionization mass spectrometry, elemental analysis and H-1 NMR data indicated the presence of only the intact diester compounds, suggesting that the formation of the hydrolysis product was an instrumental artifact, i.e., in-beam hydrolysis during ESI or a result of longer ion residence times of the ion trap mass analyzer. Copyright (C) 2003 John Wiley Sons, Ltd.
