Methods for clinical assessment of insulin sensitivity and β-cell function
Methods for clinical assessment of insulin sensitivity and β-cell function
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DOI：
10.1016/s1521-690x(03)00042-3
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发表时间：
2003-09-01
影响因子：
7.4
通讯作者：
Mari, A
中科院分区：
文献类型：
--
作者：
Pacini, G;Mari, A
胰岛素敏感性(IS)和P细胞功能(BCF)的定量评估是代谢紊乱研究的基础。描述了用于评估IS和BCF的最相关的实验测试和数据分析方法，并讨论了它们的特点。对每种方法的优点和局限性进行了比较，以帮助研究者选择最适合他们需要的测试。文中还讨论了将BCF与IS适当关联的问题。特别关注的是口服葡萄糖耐量试验，它最近受到了相当大的关注。强调了数学模型在IS和BCF评估中的作用。
The quantitative assessment of insulin sensitivity (IS) and P-cell function (BCF) is fundamental in the study of metabolic disorders. The most relevant experimental tests and data analysis methods for assessing both IS and BCF are described and their characteristic features discussed. Advantages and limitations of each method are comparatively reviewed to help investigators choose the most suitable test for their needs. The problem of properly relating BCF to IS is also addressed. Particular attention is paid to the oral glucose tolerance test, which has recently received considerable interest. The role of mathematical models in IS and BCF assessment is also emphasized.