Influence of male sex and parental allergic disease on childhood wheezing:: role of interactions
Influence of male sex and parental allergic disease on childhood wheezing:: role of interactions
复制标题
DOI：
10.1111/j.1365-2222.2004.01957.x
复制
发表时间：
2004-06-01
影响因子：
6.1
通讯作者：
Wickman, M
中科院分区：
文献类型：
--
作者：
Melén, E;Kere, J;Wickman, M
背景据报道，男孩更容易在童年时喘息，而女孩在晚年更容易受到影响。目的探讨男性和父母过敏性疾病对儿童喘息发生的影响。方法采用前瞻性研究BAMSE，对出生于斯德哥尔摩的4089名婴儿进行研究。关于父母过敏性疾病的数据是从孩子出生时回答的问卷以及1、2和4岁时喘息的症状获得的。结果儿童反复发作、一过性发作(n=266)、早发性持续性喘息(n=319)和迟发性喘息(n=195)。在所有喘息组中，男孩的比例过高(优势比，OR=1.4-1.5)，母亲和父亲的过敏性疾病对喘息的结果都很重要。母亲过敏性疾病的主要影响仅见于持续喘息的儿童。男性与父母过敏性疾病之间的交互作用超过加性作用，特别是在有持续性喘息的儿童中(OR=2.9和95%可信区间，有父母史的男孩的CI 95%2.1~4.0，女孩的OR=1.4，CI 95%1.0~2.1)。在对吸入性过敏原致敏的4岁喘息儿童中，也观察到男性与父母过敏性疾病之间的交互作用。结论我们的数据提示儿童喘息时男性与父母过敏性疾病之间存在交互作用，这可能是性别特异性的遗传影响。
Background Boys have been reported to be more susceptible to childhood wheezing, whereas girls are more susceptible later in life. This difference might be related to both genetic and environmental factors.Objective To investigate the influence of male sex and parental allergic disease on the development of childhood wheezing.Methods Infants (n=4089) born in Stockholm were recruited in a prospective study, BAMSE. Data on parental allergic diseases were obtained from questionnaires answered at the children's birth and on symptoms of wheezing at 1, 2 and 4 years of age. Sensitization to inhalant allergens and lung function was investigated at the age of 4 years.Results Children were classified as having recurrent, transient (n = 266), early-onset persistent (n = 319) and late-onset wheezing (n = 195). Boys were over-represented in all groups of wheezing (odds ratio, OR = 1.4-1.5) and both maternal and paternal allergic disease was of importance for the wheezing outcomes. A dominating influence from maternal allergic disease was only seen in children with persistent wheezing. An interaction exceeding additivity was found between male sex and parental allergic disease, particularly in children with persistent wheezing (OR=2.9 and 95% confidence interval, CI 95% 2.1-4.0 for boys with any parental history vs. OR = 1.4, CI 95% 1.0-2.1 for girls). Interaction between male sex and parental allergic disease was also observed in children who wheezed at the age of 4 years and were sensitized to inhalant allergens.Conclusion Our data suggest an interaction between male sex and parental allergic disease in childhood wheezing, which may represent a sex-specific genetic influence.