HOMOSEXUAL MOUNTING BEHAVIOR INDUCED IN MALE RATS AND RABBITS BY A TRYPTOPHAN-FREE DIET
HOMOSEXUAL MOUNTING BEHAVIOR INDUCED IN MALE RATS AND RABBITS BY A TRYPTOPHAN-FREE DIET
复制标题
DOI：
10.1016/0024-3205(77)90518-5
复制
发表时间：
1977-01-01
期刊：
影响因子：
6.1
通讯作者：
GESSA, GL
中科院分区：
文献类型：
--
作者：
FRATTA, W;BIGGIO, G;GESSA, GL
在大鼠和兔子中，摄入除色氨酸外含有所有氨基酸的饮食会导致脑5-羟色胺、色氨酸和5-羟基吲哚乙酸的显著消耗。这种效应持续超过24小时。在5-羟色胺最大耗竭时，观察到大鼠和家兔的雄性对雄性的坐骑行为显著增加。这种反应可以通过给予5-羟色氨酸（直接的5-羟色胺前体）来预防。这一发现支持了大脑5-羟色胺在控制男性性行为中起抑制作用的假设。不含色氨酸的饮食可能为研究血清素在不同类型行为中的作用提供了一种非药理学工具。
The ingestion of a diet containing all amino acids but tryptophan causes a marked depletion of brain serotonin, tryptophan and 5-hydroxy-indoleacetic acid both in rats and rabbits. This effect persists for more than 24 h. At the time of maximal serotonin depletion, a marked increase in male to male mounting behavior both in rats and rabbits was observed. This response was prevented by the administration of 5-hycroxytryptophan, the direct serotonin precursor. This finding supports the hypothesis that brain serotonin plays a inhibitory role in controlling male sexual behavior. Tryptophan-free diets may provide a non-pharmacological tool for studying the role of serotonin in different types of behavior.