The Potential Therapeutic Effects of Artesunate on Stroke and Other Central Nervous System Diseases.
The Potential Therapeutic Effects of Artesunate on Stroke and Other Central Nervous System Diseases.
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青蒿琥酯对中风和其他中枢神经系统疾病的潜在治疗作用
DOI：
10.1155/2016/1489050
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发表时间：
2016
影响因子：
--
通讯作者：
Chen Y
中科院分区：
文献类型：
--
作者：
Zuo S;Li Q;Liu X;Feng H;Chen Y
青蒿琥酯因其高效、低毒、耐受性好而成为治疗脑型疟疾和其他各种重症疟疾的重要药物。大量的研究指出，它具有广泛的药理活性，如抗寄生虫、抗肿瘤、抗炎、抗菌等。众所周知，神经系统疾病的发生、发展往往涉及复杂的病理生理机制和多种病因。近年来的研究表明，作用机制单一、副作用严重的药物不适合作为神经系统疾病的治疗药物。因此，青蒿琥酯的多能作用可能导致其在预防和治疗这些神经系统疾病中发挥重要作用。本文综述了青蒿琥酯的主要药理作用机制及其对神经系统疾病的潜在治疗作用。同时，对青蒿素及其衍生物的作用机制进行了简要综述。我们希望，在此综述中提出的证据，青蒿琥酯在预防和治疗神经系统疾病的作用，可以进一步探索和研究在可预见的未来。
Artesunate is an important agent for cerebral malaria and all kinds of other severe malaria because it is highly efficient, lowly toxic, and well-tolerated. Loads of research pointed out that it had widespread pharmacological activities such as antiparasites, antitumor, anti-inflammation, antimicrobes activities. As we know, the occurrence and development of neurological disorders usually refer to intricate pathophysiologic mechanisms and multiple etiopathogenesis. Recent progress has also demonstrated that drugs with single mechanism and serious side-effects are not likely the candidates for treatment of the neurological disorders. Therefore, the pluripotent action of artesunate may result in it playing an important role in the prevention and treatment of these neurological disorders. This review provides an overview of primary pharmacological mechanism of artesunate and its potential therapeutic effects on neurological disorders. Meanwhile, we also briefly summarize the primary mechanisms of artemisinin and its derivatives. We hope that, with the evidence presented in this review, the effect of artesunate in prevention and curing for neurological disorders can be further explored and studied in the foreseeable future.