Primary intracranial leiomyosarcoma in an immunocompetent patient: case report
Primary intracranial leiomyosarcoma in an immunocompetent patient: case report
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DOI：
10.1007/s11060-010-0450-z
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发表时间：
2011-07-01
影响因子：
3.9
通讯作者：
Yoshimine, Toshiki
中科院分区：
文献类型：
--
作者：
Fujimoto, Yasunori;Hirato, Junko;Yoshimine, Toshiki
我们报告一个颅内平滑肌肉瘤（LMS）后产生的神经纤维瘤切除小脑脑桥角。一名45岁的免疫功能正常的妇女在另一家医院切除肿瘤9年后复发。磁振造影显示左侧桥小脑角有一不均匀强化的硬脑膜肿块。肿瘤通过外侧枕下开颅术次全切除。根据组织学和免疫组化结果诊断LMS。术后，尽管患者接受了局部放疗，但由于肿瘤快速再生而死亡。对第一次手术中获得的标本进行重新评估，诊断为神经纤维瘤。LMS和神经纤维瘤都很少发生在颅内。LMS通常被认为来自血管的平滑肌细胞或多能间充质细胞。在这种情况下，LMS也可能起源于神经纤维瘤血管的平滑肌细胞，可能与先前手术期间的机械和/或热刺激有关。
We report a case of intracranial leiomyosarcoma (LMS) arising after resection of neurofibroma at the cerebellopontine angle. A 45-year-old immunocompetent woman presented with recurrence of a tumor 9 years after resection performed in another hospital. Magnetic resonance imaging demonstrated a heterogeneously enhancing, dura-based mass at the left cerebellopontine angle. The tumor was subtotally removed via lateral suboccipital craniotomy. LMS was diagnosed based on histological and immunohistochemical findings. Postoperatively, although the patient was treated using local radiotherapy, she died due to rapid regrowth of the tumor. Reevaluation of the specimen obtained in the first operation led to a diagnosis of neurofibroma. Both LMS and neurofibroma rarely occur intracranially. LMS is generally thought to arise from smooth muscle cells of the blood vessels or pluripotent mesenchymal cells. In this case, LMS might also have originated from smooth muscle cells of the vessels in the neurofibroma, possibly associated with mechanical and/or heat stimulation during the previous surgery.