Aggressive and nonaggressive personalities differ in oxidative status in selected lines of mice (Mus musculus)
Aggressive and nonaggressive personalities differ in oxidative status in selected lines of mice (Mus musculus)
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DOI：
10.1098/rsbl.2007.0513
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发表时间：
2008-02-23
期刊：
影响因子：
3.3
通讯作者：
Koolhaas, Jaap M.
中科院分区：
文献类型：
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作者：
Costantini, David;Carere, Claudio;Koolhaas, Jaap M.
选择攻击和应对（长攻击潜伏期（LAL），反应性应对策略；短攻击潜伏期（SAL），主动应对策略）的小鼠是研究动物性格生理背景的有用模型。这些小鼠还表现出不同的应激反应性，特别是在下丘脑-垂体-肾上腺轴对各种挑战的反应性方面。由于应激反应会增加活性氧的产生，我们预测细胞系的基本氧化状态可能会有所不同。我们发现，LAL 比 SAL 表现出更高的血清抗氧化能力（OXY），而活性氧代谢物（ROM）或 ROM 与 OXY 之间的平衡没有差异，反映了氧化应激。此外，这些线显示了 ROM 或 OXY 与根据年龄校正的体重之间的反比关系。结果表明，氧化状态的变化是可遗传的，并且与性格有关。这表明不同的动物性格可能伴随着氧化状态的差异，这可能预测寿命的差异。
Mice selected for aggression and coping (long attack latency (LAL), reactive coping strategy; short attack latency (SAL), pro-active coping strategy) are a useful model for studying the physiological background of animal personalities. These mice also show a differential stress responsiveness, especially in terms of hypothalamic -pituitary -adrenal axis reactivity, to various challenges. Since the stress response can increase the production of reactive oxygen species, we predicted that the basic oxidative status of the lines could differ. We found that LAL showed higher serum antioxidant capacity (OXY) than SAL, while no differences emerged for reactive oxygen metabolites (ROMs) or the balance between ROMs and OXY, reflecting oxidative stress. Moreover, the lines showed inverse relationships between ROMs or OXY and body mass corrected for age. The results indicate that variation in oxidative status is heritable and linked to personality. This suggests that different animal personalities may be accompanied by differences in oxidative status, which may predict differences in longevity.