A U6 snRNA gene with an internal promoter is juxtaposed to an snRNP protein sequence within an intron of a human G protein gene.
A U6 snRNA gene with an internal promoter is juxtaposed to an snRNP protein sequence within an intron of a human G protein gene.
复制标题
具有内部启动子的 U6 snRNA 基因与人 G 蛋白基因内含子内的 snRNP 蛋白序列并置。
DOI：
10.1093/nar/19.11.2869
复制
发表时间：
1991
影响因子：
14.9
通讯作者：
Stanford,DR
中科院分区：
文献类型：
--
作者：
Wieben,ED;Vrabel,AM;Holicky,EL;Klisak,I;Sparkes,RS;Stanford,DR
A complex locus on human chromosome 1 brings together sequences homologous to a G protein and two components of the RNA processing machinery of eukaryotic cells. Specifically, the seventh intron of the human Gi3α gene contains a fusion of a partial snRNP E protein pseudogene to a variant U6 snRNA gene. The novel U6 sequence contains nine point mutations and a one nucleotide deletion relative to the major U6 gene from humans. Unlike all other vertebrate U6 genes characterized to date, the variant U6 gene is efficiently transcribed by RNA polymerase III even in the absence of all natural flanking sequences. The union of elements from the signal transduction pathway and the RNA processing machinery suggests the possibility of functional interplay.
