The C-elegans glutamate receptor subunit NMR-1 is required for slow NMDA-activated currents that regulate reversal frequency during locomotion
The C-elegans glutamate receptor subunit NMR-1 is required for slow NMDA-activated currents that regulate reversal frequency during locomotion
复制标题
DOI：
10.1016/s0896-6273(01)00394-4
复制
发表时间：
2001-08-30
期刊：
影响因子：
16.2
通讯作者：
Maricq, AV
中科院分区：
文献类型：
--
作者：
Brockie, PJ;Mellem, JE;Maricq, AV
谷氨酸受体的N-甲基-D-天冬氨酸（NMDA）亚型对突触可塑性和神经系统发育和功能非常重要。我们已经使用遗传学和电生理学的方法来证明，NMR-1，秀丽隐杆线虫NMDA型离子型谷氨酸受体亚基，在运动和觅食行为的控制中发挥作用。NMR-1突变体显示出较低的从向前运动切换到向后运动的概率和降低的在复杂环境中导航的能力。从中间神经元AVA的电记录表明，NMDA依赖性电流选择性破坏nmr-1突变体。我们还表明，一个缓慢脱敏的非NMDA受体的变体可以挽救nmr-1突变表型。我们认为C.秀丽线虫在觅食行为期间提供调节运动逆转频率的长寿命电流。
The N-methyl-D-aspartate (NMDA) subtype of glutamate receptor is important for synaptic plasticity and nervous system development and function. We have used genetic and electrophysiological methods to demonstrate that NMR-1, a Caenorhabditis elegans NMDA-type ionotropic glutamate receptor subunit, plays a role in the control of movement and foraging behavior. nmr-1 mutants show a lower probability of switching from forward to backward movement and a reduced ability to navigate a complex environment. Electrical recordings from the interneuron AVA show that NMDA-dependent currents are selectively disrupted in nmr-1 mutants. We also show that a slowly desensitizing variant of a non-NMDA receptor can rescue the nmr-1 mutant phenotype. We propose that NMDA receptors in C. elegans provide long-lived currents that modulate the frequency of movement reversals during foraging behavior.