Interspecies Comparative Analyses Reveal Distinct Carbohydrate-Responsive Systems among Drosophila Species.
Interspecies Comparative Analyses Reveal Distinct Carbohydrate-Responsive Systems among Drosophila Species.
复制标题
种间比较分析揭示了果蝇物种之间独特的碳水化合物反应系统。
DOI：
10.1016/j.celrep.2019.08.030
复制
发表时间：
2019
期刊：
影响因子：
8.8
通讯作者：
Yukako Hattori
中科院分区：
文献类型：
--
作者：
Kaori Watanabe;Yasutetsu Kanaoka;Shoko Mizutani;Hironobu Uchiyama;Shunsuke Yajima;Masayoshi Watada;Tadashi Uemura;Yukako Hattori
在进化过程中，生物体获得了不同的食性。有些物种是适应各种食物资源的营养通才，而另一些物种则是专家，以特定资源为食。然而，关于多面手如何适应多样化的饮食，还有很多东西有待发现。我们发现，一般果蝇和拟果蝇的幼虫在三种营养平衡不同的食物中发育，而特化果蝇和秀丽果蝇不能在富含碳水化合物的食物中发育。黑腹果蝇通过转化生长因子β（transforming growth factor β，TGF-β）/Activin信号系统下调多种代谢基因的表达，维持代谢稳态，成功适应饮食。相比之下，专门的D. sechellia以更高的水平表达这些代谢基因，并在富含碳水化合物的饮食中积累各种代谢物，最终导致适应能力降低。表型的相似性和差异强烈表明，强大的碳水化合物响应的调节系统是进化保留通过基因组-环境相互作用的通才，并有助于他们的营养适应性。
During evolution, organisms have acquired variable feeding habits. Some species are nutritional generalists that adapt to various food resources, while others are specialists, feeding on specific resources. However, much remains to be discovered about how generalists adapt to diversified diets. We find that larvae of the generalistsDrosophila melanogasterandD. simulansdevelop on three diets with different nutrient balances, whereas specialistsD. sechelliaandD. eleganscannot develop on carbohydrate-rich diets. The generalistD. melanogasterdownregulates the expression of diverse metabolic genes systemically by transforming growth factor β (TGF-β)/Activin signaling, maintains metabolic homeostasis, and successfully adapts to the diets. In contrast, the specialistD. sechelliaexpresses those metabolic genes at higher levels and accumulates various metabolites on the carbohydrate-rich diet, culminating in reduced adaptation. Phenotypic similarities and differences strongly suggest that the robust carbohydrate-responsive regulatory systems are evolutionarily retained through genome-environment interactions in the generalists and contribute to their nutritional adaptabilities.