Relationship between motor learning and gambling propensity in Parkinson’s disease
Relationship between motor learning and gambling propensity in Parkinson’s disease
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DOI：
10.1080/13803395.2022.2083083
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发表时间：
2022-01
影响因子：
2.2
通讯作者：
N. Ueda;Y. Higashiyama;A. Saito;K. Kimura;Y. Nakae;Masanao Endo;H. Joki;Chiharu Kugimoto;H. Kishida;H. Doi;H. Takeuchi;S. Koyano;F. Tanaka
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作者：
N. Ueda;Y. Higashiyama;A. Saito;K. Kimura;Y. Nakae;Masanao Endo;H. Joki;Chiharu Kugimoto;H. Kishida;H. Doi;H. Takeuchi;S. Koyano;F. Tanaka
摘要 简介 基底神经节和相关的多巴胺能皮层区域是运动学习的重要神经系统，也与冲动控制障碍（ICD）有关。帕金森病 (PD) 中经常观察到运动学习障碍和 ICD。然而，运动学习能力与 ICD 之间的关系尚未阐明。方法 我们检查了 PD 患者运动学习能力和赌博倾向（ICD 前驱期的可能症状）之间的关系。对 59 名没有临床 ICD 的 PD 患者和 43 名正常对照 (NC) 进行视觉运动旋转扰动任务和爱荷华州赌博任务 (IGT)，分别评估运动学习能力和赌博倾向。参与者还进行了额外的认知评估并接受了脑灌注 SPECT 成像。结果 在 PD 患者中，更好的运动学习能力与较低的 IGT 分数（即较高的赌博倾向）显着相关，但在 NC 患者中则不然。反映前额叶功能和前额区血液灌注保存良好的评估得分较高，与较低的 IGT 得分以及较好的运动学习能力相关。结论 我们的研究结果表明，更好的运动学习能力和更高的赌博倾向是基于更好的前额叶功能，这与前额叶皮层是运动学习和 ICD 的共同重要区域之一的理论是一致的。
ABSTRACT Introduction The basal ganglia and related dopaminergic cortical areas are important neural systems underlying motor learning and are also implicated in impulse control disorders (ICDs). Motor learning impairments and ICDs are frequently observed in Parkinson’s disease (PD). Nevertheless, the relationship between motor learning ability and ICDs has not been elucidated. Methods We examined the relationship between motor learning ability and gambling propensity, a possible symptom for prodromal ICDs, in PD patients. Fifty-nine PD patients without clinical ICDs and 43 normal controls (NC) were administered a visuomotor rotation perturbation task and the Iowa Gambling Task (IGT) to evaluate motor learning ability and gambling propensity, respectively. Participants also performed additional cognitive assessments and underwent brain perfusion SPECT imaging. Results Better motor learning ability was significantly correlated with lower IGT scores, i.e., higher gambling propensity, in PD patients but not in NC. The higher scores on assessments reflecting prefrontal lobe function and well-preserved blood perfusion in prefrontal areas were correlated with lower IGT scores along with better motor learning ability. Conclusions Our findings suggest that better motor learning ability and higher gambling propensity are based on better prefrontal functions, which are in accordance with the theory that the prefrontal cortex is one of the common essential regions for both motor learning and ICDs.