Low dose sodium valproate in the treatment of juvenile myoclonic epilepsy
Low dose sodium valproate in the treatment of juvenile myoclonic epilepsy
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DOI：
10.1007/s004150200028
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发表时间：
2002-04
影响因子：
6
通讯作者：
Anna D. Karlovassitou-Koniari;D. Alexiou;P. Angelopoulos;Pantelis Armentsoudis;Evangelia Dimitrakoudi;I. Delithanasis;P. Hamlatzis;Stavros J. Baloyannis
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文献类型：
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作者：
Anna D. Karlovassitou-Koniari;D. Alexiou;P. Angelopoulos;Pantelis Armentsoudis;Evangelia Dimitrakoudi;I. Delithanasis;P. Hamlatzis;Stavros J. Baloyannis
14 名青少年肌阵挛性癫痫 (JME) 患者接受单次低剂量丙戊酸钠缓释制剂（VPA，每日 500 毫克）治疗。低剂量治疗开始的平均年龄为 19.2 岁（范围 14-26 岁）。在此治疗之前，6名患者已接受高剂量VPA治疗超过2年，3名患者接受1至2年，3名患者不到1年，2名患者从低剂量开始治疗。低剂量治疗的平均持续时间为 35.6 个月（范围 25-59 个月）。 （所有患者仍在接受药物治疗）。所有患者的全身强直阵挛发作和失神发作均得到控制。肌阵挛性抽搐仅在一名患者中复发，她是一位年轻的母亲，她正在照顾刚出生的婴儿，睡眠不足。尚未报告不良反应。我们建议JME患者可以通过单次低剂量VPA（每日500毫克）有效治疗，同时应避免睡眠不足和饮酒等癫痫发作诱发因素。
Fourteen patients with juvenile myoclonic epilepsy (JME) were treated with a single low dose of a sustained-release preparation of sodium valproate (VPA, 500 mg daily). The mean age of the onset of the low dose treatment was 19.2 years (range 14–26). Before this treatment, six patients had been treated with high dose VPA for a period of more than 2 years, three patients for 1 to 2 years, three patients less than 1 year and two patients initiated the treatment from the begining with a low dose. The mean duration of low dose treatment is 35.6 months (range 25–59 months). (All patients are still under medication). Generalized tonic-clonic and absence seizures were controlled in all patients. Myoclonic jerks relapsed only in one patient, a young mother who was looking after her newly born baby and was deprived of sleep. No adverse reactions have been reported. We suggest that JME patients can effectively be treated with single low VPA dose (500 mg daily), while at the same time seizure precipitating factors, such as sleep deprivation and alcohol ingestion, should be avoided.