A rehabilitation of the genetic map of the 84B-D region in Drosophila melanogaster.
A rehabilitation of the genetic map of the 84B-D region in Drosophila melanogaster.
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DOI：
10.1093/genetics/114.1.111
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发表时间：
1986-09
期刊：
影响因子：
3.3
通讯作者：
D. Cavener;D. Otteson;T. Kaufman
中科院分区：
文献类型：
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作者：
D. Cavener;D. Otteson;T. Kaufman
通过对果蝇多线染色体84 B3 - 84 D3，5区域的重新分析，鉴定并定位了16个基因。这些基因包括11个重要的基因座，四个基因表现出非致死性的可见突变表型和一个基因编码的非必需酶。两个重要基因的基因产物的身份已被确定为α-微管蛋白和葡萄糖脱氢酶（Gld）。三个新发现的基因，粘（stk），半出（hat）和捕获（ted），以及Gld是羽化所必需的。在非必需基因中，有粗糙眼（roe）和皱眼（芸香），它们影响眼睛的质地。同时删除84 E中的卵和一个未识别的位点，可以大大增强卵的表型。另一个非必需基因，圆形基因（rn）的突变，其特征是大多数成体附肢的模式缺失。
A reanalysis of the 84B3 to 84D3,5 region of the polytene chromosomes of Drosophila melanogaster has led to the identification and localization of 16 genes. These genes include 11 vital loci, four genes exhibiting nonlethal visible mutant phenotypes and one gene encoding a nonessential enzyme. The identity of the gene products of two of the vital genes has been determined to be alpha-tubulin and glucose dehydrogenase (Gld). Three newly identified genes, sticking (stk), half out (hat) and trapped (ted), as well as Gld are required for eclosion. Among the nonessential genes are roughened eye (roe) and ruffed eye (rue), which affect eye texture. The roe phenotype is greatly enhanced by deletions that simultaneously remove roe and an unidentified locus in 84E. Mutations in another nonessential gene, rotund (rn), are characterized by pattern deletions of most adult appendages.