WINCS Harmoni: Closed-loop dynamic neurochemical control of therapeutic interventions.
WINCS Harmoni: Closed-loop dynamic neurochemical control of therapeutic interventions.
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DOI：
10.1038/srep46675
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发表时间：
2017-04-28
影响因子：
4.6
通讯作者：
Bennet KE
中科院分区：
文献类型：
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作者：
Lee KH;Lujan JL;Trevathan JK;Ross EK;Bartoletta JJ;Park HO;Paek SB;Nicolai EN;Lee JH;Min HK;Kimble CJ;Blaha CD;Bennet KE
在了解神经递质在正常和病理脑功能中的作用方面已经取得了重大进展。然而，旨在改善治疗干预措施的临床前试验并没有利用动态大脑过程中的实时体内神经化学变化，如疾病进展和对药物、认知、行为和神经调节治疗的反应。这部分是由于缺乏灵活的研究工具，无法在体内测量脑化学的动态变化。在这里，我们提出了一个研究平台，WINCS Harmoni，它可以同时测量体内多个解剖靶点的神经化学活动，以研究正常和病理脑功能。此外，WINCS Harmoni可以通过其同步刺激和神经化学传感能力，为神经化学水平的闭环控制提供实时神经化学反馈。我们在非人类灵长类动物、猪和啮齿动物的深部脑刺激（DBS）模型中展示了该平台的这些和其他关键特征。最终，像这里描述的系统将提高我们对神经疾病和治疗干预背景下脑生理学动力学的理解，这可能会导致精准医学和个性化治疗的发展，以获得最佳的治疗效果。
There has been significant progress in understanding the role of neurotransmitters in normal and pathologic brain function. However, preclinical trials aimed at improving therapeutic interventions do not take advantage of real-time in vivo neurochemical changes in dynamic brain processes such as disease progression and response to pharmacologic, cognitive, behavioral, and neuromodulation therapies. This is due in part to a lack of flexible research tools that allow in vivo measurement of the dynamic changes in brain chemistry. Here, we present a research platform, WINCS Harmoni, which can measure in vivo neurochemical activity simultaneously across multiple anatomical targets to study normal and pathologic brain function. In addition, WINCS Harmoni can provide real-time neurochemical feedback for closed-loop control of neurochemical levels via its synchronized stimulation and neurochemical sensing capabilities. We demonstrate these and other key features of this platform in non-human primate, swine, and rodent models of deep brain stimulation (DBS). Ultimately, systems like the one described here will improve our understanding of the dynamics of brain physiology in the context of neurologic disease and therapeutic interventions, which may lead to the development of precision medicine and personalized therapies for optimal therapeutic efficacy.