Outcome and six month follow up of patients after Ultra Rapid Opiate Detoxification (URODSM)
Outcome and six month follow up of patients after Ultra Rapid Opiate Detoxification (URODSM)
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DOI：
10.1300/j069v19n02_02
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发表时间：
2000-01-01
影响因子：
2.3
通讯作者：
Eustace, JC
中科院分区：
文献类型：
--
作者：
Albanese, AP;Gevirtz, C;Eustace, JC
目标-（1）评估超快速阿片戒毒（UROD）的安全性和有效性； (2)评估选择该方法的患者六个月的结果数据。设计——两中心平行组临床试验。无赠款资助。设置 - 两个学术医疗中心。参与者 - 93 名男性和 27 名女性，年龄 18 至 55 岁，有阿片类药物依赖，自行选择接受戒毒。干预措施 - UROD，随后是纳曲酮维持和善后计划。 UROD 和术后护理费用由患者和/或其重要他人负责。 主要结果测量-(1) UROD 的完成，根据麻醉下对纳洛酮激发试验的非反应性反应和出院前对纳曲酮给药的非反应性反应来确定。 (2) 患者结果：根据 UROD 患者自我报告的无复发状态随访六个月确定，通过尿液药物筛查、其他重要报告和/或治疗师报告确认。结果 - UROD 100% 成功戒毒，发病率低，无死亡率。可获得 111/123 例手术 (90%) 的复发数据，其中 61/111 名患者 (55%) 在六个月的随访间隔内报告无复发状态。结论 - 对于阿片类药物成瘾的个体，超快速阿片戒毒方法似乎是一种可行的治疗选择。
Objectives-(1) Evaluate the safety and efficacy of Ultra Rapid Opiate Detoxification (UROD); and (2) evaluate six month outcome data of patients choosing this method.Design-Two center parallel group clinical trial. No grant funding.Setting-Two academic medical centers.Participants-Ninety-three men and 27 women, aged 18 to 55 years, with opiate dependency self selected to undergo detoxification.Interventions-UROD followed by naltrexone maintenance and an aftercare program. UROD and aftercare costs were the responsibility of the patients and/or their significant others.Main Outcomes Measure-(1) Completion of UROD as determined by a non reactive response to a naloxone challenge test under anesthesia and non reactive response to naltroxone administration before discharge. (2) Patient outcome: as determined at six month follow up of UROD patients' self reported relapse free status confirmed by urine drug screen, significant other reports, and/or therapist reports.Results-One hundred percent successful detoxification with UROD with low morbidity and no mortality. Relapse data were available for 111/123 procedures performed (90%), with 61/111 patients (55%) with reported relapse free status at the six month follow up interval.Conclusions-For individuals who are addicted to opioids, the Ultra Rapid Opiate Detoxification method appears to be a viable treatment option.