Nok plays an essential role in maintaining the integrity of the outer nuclear layer in the zebrafish retina
Nok plays an essential role in maintaining the integrity of the outer nuclear layer in the zebrafish retina
复制标题
DOI：
10.1016/j.exer.2005.10.030
复制
发表时间：
2006-07-01
影响因子：
3.4
通讯作者：
Li, Lihua
中科院分区：
文献类型：
--
作者：
Wei, Xiangyun;Zou, Jian;Li, Lihua
脊椎动物视网膜的正常视觉功能需要维持视网膜外核层（ONL）的完整性，其经常在许多致盲人类视网膜疾病中受到影响。虽然ONL的结构完整性一直被认为主要通过外界膜（OLM）来维持，但我们对OLM本身的发展和维持知之甚少。在这里，通过分析斑马鱼N-cad和nok突变体中光感受器的粘附特性，我们首次证明了nok基因对于OLM的建立和/或维持是必不可少的。此外，我们的研究结果意味着的可能性，诺克，面包屑，和它们的相关蛋白可能构成一种类型的光感受器感光连接复合物，以前没有被描述。因此，我们的研究提供了新的见解ONL的完整性是保持在脊椎动物视网膜的机制。(c)2006爱思唯尔有限公司保留所有权利。
Proper visual function of the vertebrate retina requires the maintenance of the integrity of the retinal outer nuclear layer (ONL), which is often affected in many blinding human retinal diseases. While the structural integrity of the ONL has long been considered to be maintained primarily through the outer limiting membrane (OLM), we have little knowledge on the development and maintenance of the OLM itself. Here, by analyzing the adhering properties of photoreceptors in zebrafish N-cad and nok mutants, we demonstrated for the first time that the nok gene is essential for the establishment and/or maintenance of the OLM. In addition, our results imply the possibility that Nok, Crumbs, and their associated proteins may constitute a type of photoreceptor-photoreceptor junctional complex that has not be described before. Thus, our study provides novel insights into the mechanisms by which the integrity of the ONL is maintained in the vertebrate retina. (c) 2006 Elsevier Ltd. All rights reserved.