Catalytic Asymmetric Conjugate Allylation of Coumarins
Catalytic Asymmetric Conjugate Allylation of Coumarins
复制标题
香豆素的催化不对称共轭烯丙基化
DOI：
10.1021/ol201312y
复制
发表时间：
2011-08-05
期刊：
影响因子：
5.2
通讯作者：
Feng, Xiaoming
中科院分区：
文献类型：
--
作者：
Kuang, Yulong;Liu, Xiaohua;Feng, Xiaoming
采用催化不对称共轭烯丙基化反应合成了具有潜在生物活性的4-烯丙基-2-氧代苯并二氢吡喃骨架。采用双重活化策略，分别用N，N '-二氧化物Yb（OTf）（3）活化香豆素和（CuOTf）（2）中心点C7 H8通过金属转移活化四烯丙基锡。在温和的条件下得到了较好的产率和对映选择性。
A catalytic asymmetric conjugate allylation was successfully developed to synthesize potential pharmacologically active 4-allyl-2-oxochroman skeletons. A dual activation strategy was employed by using N,N'-dioxide-Yb(OTf)(3) to activate coumarins and using (CuOTf)(2)center dot C7H8 to activate tetraallyltin via transmetalation, respectively. Good yields and enantioselectivities were obtained under mild conditions.