Acute and delayed effects of exercise on human melatonin secretion
Acute and delayed effects of exercise on human melatonin secretion
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DOI：
10.1177/074873049701200611
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发表时间：
1997-12-01
影响因子：
3.5
通讯作者：
VanCauter, E
中科院分区：
文献类型：
--
作者：
Buxton, OM;LHermiteBaleriaux, M;VanCauter, E
越来越多的证据表明，运动可能对人体褪黑激素的分泌有快速和延迟的影响。的确，锻炼可能是急性的（即，几分钟内）改变褪黑激素水平并导致12至24小时后夜间褪黑激素发作的转变。急性和延迟效应的存在和性质似乎取决于运动的时间。可检测到的急性效应的存在还取决于运动的持续时间、强度和类型。在褪黑激素分泌的上升阶段进行晚间运动可能会降低褪黑激素水平。当褪黑激素水平已经升高时，在夜间进行高强度运动会持续导致褪黑激素水平进一步升高（近50%）。在同一昼夜节律阶段进行的低强度运动没有影响。无论强度如何，在褪黑激素分泌的偏移附近或在白天运动对褪黑激素分泌没有一致的急性影响。夜间运动，无论是中等强度还是高强度，都会导致第二天晚上褪黑激素发作的相位延迟。夜间运动后第二天褪黑激素开始的转变代表内在昼夜节律定时的转变，这一概念的支持是观察到促甲状腺激素分泌的昼夜节律升高的开始可以同时观察到类似的相移（在方向和幅度上）。因此，运动引起的褪黑激素分泌开始时的相移的观察被解释为证据，即在人类和啮齿动物中，在习惯性休息期间增加的体力活动能够改变生物钟功能。
Accumulating evidence suggests that exercise may have both rapid and delayed effects on human melatonin secretion. Indeed, exercise may acutely (i.e., within minutes) alter melatonin levels and result in a shift of the onset of nocturnal melatonin 12 to 24 h later. The presence and nature of both acute and delayed effects appear to be dependent on the timing of exercise. The presence of a detectable acute effect also depends on the duration, intensity, and type of exercise. Late evening exercise during the rising phase of melatonin secretion may blunt melatonin levels. High-intensity exercise during the nighttime period, when melatonin levels already are elevated, consistently results in a further (nearly 50%) elevation of melatonin levels. No effect of low-intensity exercise performed at the same circadian phase could be detected. Irrespective of intensity, exercise near the offset of melatonin secretion or during the daytime has no consistent acute effect on melatonin secretion. Nighttime exercise, whether of moderate or high intensity, results in phase delays of the melatonin onset on the next evening. In support of the concept that a shift of the melatonin onset on the day after nighttime exercise represents a shift of intrinsic circadian timing is the observation that similar phase shifts (in both direction and magnitude) may be observed simultaneously for the onset of the circadian elevation of thyrotropin secretion. The observation of exercise-induced phase shifts of the onset of melatonin secretion is, therefore, interpreted as evidence that, in humans as in rodents, increased physical activity during the habitual rest period is capable of altering circadian clock function.