PEG-PLLA and PEG-PDLA multiblock copolymers: synthesis and in situ hydrogel formation by stereocomplexation.
PEG-PLLA and PEG-PDLA multiblock copolymers: synthesis and in situ hydrogel formation by stereocomplexation.
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PEG-PLLA 和 PEG-PDLA 多嵌段共聚物：通过立体络合合成和原位水凝胶形成。
DOI：
10.1016/j.jconrel.2006.09.027
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
J. Feijen
中科院分区：
文献类型：
--
作者：
C. Hiemstra;Z. Zhong;X. Jiang;W. Hennink;P. Dijkstra;J. Feijen
合成了水溶性PEG-PLLA和PEG-PDLA多嵌段共聚物，并研究了PLLA和PDLA嵌段之间的立体络合形成原位水凝胶。临界凝胶浓度测量表明，这些多嵌段共聚物能够在比母体三嵌段共聚物低得多的浓度下形成立体络合水凝胶。此外，流变学研究表明，与在其他条件下获得的三嵌段共聚物水凝胶相比，多嵌段共聚物立体络合水凝胶的力学性能有显著改善。
Water-soluble PEG–PLLA and PEG–PDLA multiblock copolymers were synthesized and investigated for in situ hydrogel formation by stereocomplexation between the PLLA and PDLA blocks. The critical gel concentration measurements showed that these multiblock copolymers are able to form stereocomplexed hydrogels at a much lower concentration in water than the parent triblock copolymers. Furthermore, rheology studies showed significantly improved mechanical properties of the multiblock copolymer stereocomplexed hydrogels compared to the triblock copolymer hydrogels, obtained under otherwise same conditions.