Dynamic Contrast-Enhanced and Diffusion-Weighted MRI of Estrogen Receptor-Positive Invasive Breast Cancers: Associations Between Quantitative MR Parameters and Ki-67 Proliferation Status
Dynamic Contrast-Enhanced and Diffusion-Weighted MRI of Estrogen Receptor-Positive Invasive Breast Cancers: Associations Between Quantitative MR Parameters and Ki-67 Proliferation Status
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DOI：
10.1002/jmri.25348
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发表时间：
2017-01-01
影响因子：
4.4
通讯作者：
Kim, Jin You
中科院分区：
文献类型：
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作者：
Shin, Jong Ki;Kim, Jin You
目的：探讨动态对比增强磁共振成像 (DCE-MRI) 和弥散加权成像 (DWI) 定量参数与雌激素受体 (ER) 阳性浸润性乳腺癌患者 Ki-67 增殖状态之间的关系。 材料和方法：我们回顾性分析了 88 例 ER 阳性浸润性乳腺癌患者的记录。 术前在 3T 扫描仪上进行 DCE-MRI 和 DWI。记录灌注参数（K-trans、K-ep 和 V-e）和表观扩散系数 (ADC)，并将这些数据与 Ki-67 状态相关联。 Ki-67 增殖指数分为高（>= 14%）或低（< 14%）。结果：在高 Ki-67 组中，平均 K-trans 显着较高（P
Purpose: To explore the association between quantitative parameters derived from dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and diffusion-weighted imaging (DWI) and Ki-67 proliferation status in patients with estrogen receptor (ER)-positive invasive breast cancer.Materials and Methods: We retrospectively reviewed the records of 88 patients with ER-positive invasive breast cancer who underwent preoperative DCE-MRI and DWI on a 3T scanner. Perfusion parameters (K-trans, K-ep, and V-e) and apparent diffusion coefficients (ADCs) were recorded, and we correlated these data with the Ki-67 status. The Ki-67 proliferation index was categorized as high (>= 14%) or low (< 14%).Results: In the high-Ki-67 group, the mean K-trans was significantly higher (P