Clinical features and outcome of mucormycosis.
Clinical features and outcome of mucormycosis.
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DOI：
10.1155/2014/562610
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发表时间：
2014
影响因子：
--
通讯作者：
Galarza-Delgado DÁ
中科院分区：
文献类型：
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作者：
Camara-Lemarroy CR;González-Moreno EI;Rodríguez-Gutiérrez R;Rendón-Ramírez EJ;Ayala-Cortés AS;Fraga-Hernández ML;García-Labastida L;Galarza-Delgado DÁ
毛霉病（MCM）是一种危及生命的感染，尽管最近在其诊断和治疗方面取得了进展，但其死亡率很高。目的是报告14例毛霉菌病感染并复习相关文献。我们回顾性分析了墨西哥北部一家三级医疗教学医院连续14例MCM患者的人口学和临床资料。患者平均年龄为39.9岁（范围5-65岁）。其中9名患者为男性。10例有糖尿病为基础疾病，6例有血液恶性肿瘤（急性白血病）。其中慢性肾功能衰竭3例，糖尿病酮症酸中毒4例。所有患者均有颅脑受累。住院死亡率为50%。所有患者均接受多烯类抗真菌药物治疗，11例患者接受手术治疗。与非幸存者相比，幸存者明显更年轻，患糖尿病的可能性更小，入院时血清白蛋白水平更高。MCM患者的临床预后较差。未控制的糖尿病和年龄是不良预后因素。
Mucormycosis (MCM) is a life-threatening infection that carries high mortality rates despite recent advances in its diagnosis and treatment. The objective was to report 14 cases of mucormycosis infection and review the relevant literature. We retrospectively analyzed the demographic and clinical data of 14 consecutive patients that presented with MCM in a tertiary-care teaching hospital in northern Mexico. The mean age of the patients was 39.9 (range 5–65). Nine of the patients were male. Ten patients had diabetes mellitus as the underlying disease, and 6 patients had a hematological malignancy (acute leukemia). Of the diabetic patients, 3 had chronic renal failure and 4 presented with diabetic ketoacidosis. All patients had rhinocerebral involvement. In-hospital mortality was 50%. All patients received medical therapy with polyene antifungals and 11 patients underwent surgical therapy. Survivors were significantly younger and less likely to have diabetes than nonsurvivors, and had higher levels of serum albumin on admission. The clinical outcome of patients with MCM is poor. Uncontrolled diabetes and age are negative prognostic factors.