Correlation of clinical and in vitro erythropoietic responses to androgens in renal failure.
Correlation of clinical and in vitro erythropoietic responses to androgens in renal failure.
复制标题
肾衰竭患者的临床和体外红细胞生成反应与雄激素的相关性。
DOI：
10.1038/ki.1982.186
复制
发表时间：
1982
影响因子：
19.6
通讯作者：
Howard,D
中科院分区：
文献类型：
--
作者：
Kalmanti,M;Dainiak,N;Martino,J;Dewey,M;Kulkarni,V;Howard,D
方法患者群体。我们最初研究了 14 名男性和 6 名患有慢性肾功能衰竭和贫血的女性，他们接受了 7 至 97 个月的维持性血液透析。在接受雄激素治疗之前获得了知情同意。他们的平均年龄为 49 岁。 10 名患者患有肾小球肾炎，3 名多囊肾患者，5 名肾硬化患者，1 名肾病综合征患者和 1 名腹膜后纤维化患者。他们的血液尿素氮平均值为 77 mg/dl（范围为 51 至 96 mg/dl）；血清肌酐为 10.9 mg/dl（范围为 6.5 至 17.4 mg/dl）；血清钙含量为 9.4 mg/dl（范围为 8.6 至 11.4 mgldl）；血清磷为 4.1 mg/dl（范围为 2.4 至 7.7 mg/dl）；碱性磷酸酶为 80 U/ml（范围为 28 至 339 U/ml）。 C 末端 PTH 检测显示平均血清甲状旁腺激素水平为 396 ng/ml（范围为 191 至 548 ng/ml）。 19 名患者使用中空纤维或线圈透析器每周 3 次透析 4 小时，临床情况稳定。一名患者在家接受板式透析器治疗，每周 3 次，每次 6 小时。在研究之前或研究期间，没有患者接受甲状旁腺切除术。表 1 显示了最初研究的 20 名患者的临床总结。两名肾小球肾炎患者患有肾病（表 1）。三名患者在研究前 4 个月至 2 年内经历了肾移植排斥（两名来自尸体，一名来自相关活体捐赠者；表 1）。所有 20 名患者的血红蛋白平均 SEM 值为 6.9 ± 0.3 g/dl；网织红细胞指数为0.3±0.38%；中性粒细胞绝对计数为 4,463 120/mm3；淋巴细胞绝对计数为 1,330 52/mm3，
Methods Patient population. We initially studied 14 males and 6 females with chronic renal failure and anemia who received maintenance hemodialysis for 7 to 97 months. Informed consent was obtained prior to their receiving androgen therapy. Their mean age was 49 years. Ten patients had glomerulonephritis, three polycystic kidney disease, five nephrosclerosis, one nephrotic syndrome and one retroperitoneal fibrosis. The mean value for their blood urea nitrogen was 77 mg/dl (with a range of 51 to 96 mg! dl); for their serum creatinine, 10.9 mg/dl (range of 6.5 to 17.4 mg/dl); for their serum calcium, 9.4 mg/dl (range of 8.6 to 11.4 mgldl); for their serum phosphorous, 4.1 mg/dl (range of 2.4 to 7.7 mg/dl); and for their alkaline phosphatase, 80 U/ml (range of 28 to 339 U/ml). C-terminal PTH assays showed a mean serum parathyroid hormone level of 396 ng/ml (range of 191 to 548 ng/ml). Nineteen patients were clinically stable on dialysis for 4 hr, three times a week with a hollow fiber or coil dialyzer. One patient was treated with a plate dialyzer for 6 hr, three times a week at home. None of the patients underwent parathyroidectomy prior to or during the study. Table 1 displays a clinical summary of the initial 20 patients studied. Two patients with glomerulonephritis were anephric (Table 1). Three patients experienced kidney transplant rejec-tions from 4 months to 2 years prior to the study (two were from cadavers and one was from a related living donor; Table 1). The mean SEM value in all 20 patients for hemoglobin was 6.9 0.3 g/dl; for their reticulocyte index, 0.3 0.38%; for their absolute neutrophil count, 4,463 120/mm3; for their absolute lymphocyte count 1,330 52/mm3, and for their