Expression of achaete and scute genes in Drosophila imaginal discs and their function in sensory organ development.
Expression of achaete and scute genes in Drosophila imaginal discs and their function in sensory organ development.
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DOI：
10.1101/gad.3.7.997
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发表时间：
1989-07
影响因子：
10.5
通讯作者：
S. Romani;S. Campuzano;E. Macagno;J. Modolell
中科院分区：
文献类型：
--
作者：
S. Romani;S. Campuzano;E. Macagno;J. Modolell
几种感觉器官(SOS)以刻板的位置出现在成年果蝇的角质层上。这些SOS的产生需要achaete(Ac)和scute(Sc)基因的活性。为了研究Ac和Sc是否也为SOS的定位提供了空间信息，我们分析了这些基因在So前体被指定的时间附近在翼想象盘中的表达模式。我们发现，这种表达与已知这些前体所在的盘中区域一致，并受其限制。在功能丧失的sc突变体中，sc RNA在单个区域中被耗尽，该区域位于应该找到被抑制的大毛类的前体的区域。此外，一些，可能是所有的SoS需要这些基因的表达才能达到最早可检测到的分化状态。这里提出的这些和其他结果，连同Ac和/或Sc表达区域的扩大导致异位SOS的发展的发现，表明Ac和Sc促进了SO前体的确定，并划定了它们可以发育的想象盘区域。
Several kinds of sensory organs (SOs) appear in stereotyped positions on the adult Drosophila cuticle. The generation of these SOs requires the activity of the achaete (ac) and scute (sc) genes. To investigate whether ac and sc also provide spatial information for the positioning of SOs, we have analyzed the patterns of expression of these genes in the wing imaginal disc around the time that SO precursors are being specified. We find that expression coincides with and is restricted to areas of the disc where these precursors are known to be located. In the loss-of-function sc mutant, sc RNA is depleted in a single area located in the region where the precursor for the suppressed macrochaeta should be found. Moreover, some, and probably all, SOs require expression of these genes to reach the earliest detectable differentiated state. These and other results presented here, together with the finding that expansion of the areas of ac and/or sc expression causes the development of ectopic SOs, indicate that ac and sc promote the determination of SO precursors and delimit the regions of the imaginal discs where they can develop.