Recovery of focal brain ischemia-induced behavioral dysfunction by intracerebroventricular injection of microglia
Recovery of focal brain ischemia-induced behavioral dysfunction by intracerebroventricular injection of microglia
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DOI：
10.1254/jphs.sc0040129
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发表时间：
2005-02-01
影响因子：
3.5
通讯作者：
Shimohama, S
中科院分区：
文献类型：
--
作者：
Kitamura, Y;Yanagisawa, D;Shimohama, S
小胶质细胞在脑实质中的功能尚未完全了解。大脑中动脉（MCA）闭塞和再灌注引起大鼠大脑皮层和纹状体大量神经元丢失的行为功能障碍。当将外源性小胶质细胞显微注射到脑室内（i.c.v.）在MCA闭塞期间，局灶性缺血诱导的行为功能障碍被显著抑制。在那个时候，许多小胶质细胞迁移到缺血性病变，小胶质细胞衍生的神经元样细胞几乎检测不到。这些结果表明，外源性小胶质细胞保护局灶性缺血诱导的神经变性和改善行为功能障碍。
The function of microglia in the brain parenchyma is not fully understood. Occlusion of the middle cerebral artery (MCA) and reperfusion caused behavioral dysfunction with massive neuronal loss in the rat cerebral cortex and striatum. When exogenous microglia were microinjected into the intracerebroventricle (i.c.v.) during MCA occlusion, focal ischemia-induced behavioral dysfunction was significantly inhibited. At that time, many microglia migrated into the ischemic lesion, and microglia-derived neuron-like cells were barely detectable. These results suggest that exogenous microglia protect against focal ischemia-induced neurodegeneration and improve behavioral dysfunction.