Study of the Skin of a New Hairless Rat Mutant
Study of the Skin of a New Hairless Rat Mutant
复制标题
新无毛鼠突变体的皮肤研究
DOI：
10.1111/j.1346-8138.1988.tb03687.x
复制
发表时间：
1988
期刊：
影响因子：
--
通讯作者：
I. Hatayama
中科院分区：
文献类型：
--
作者：
K. Hanada;S. Chiyoya;Kenji Suzuki;I. Hashimoto;I. Hatayama
对新建立的无毛大鼠（Hirosaki无毛大鼠；HHR）的皮肤进行组织学和免疫学检查。突变鼠皮肤的外观与人类皮肤相似，有皱纹和很少的牛皮毛。在真皮中部散在的扩张性滤泡囊肿是最主要的显微镜变化。电镜下，部分基底细胞细胞质中含有许多卵圆形细胞器，但其作用尚不清楚。表皮可见朗格汉斯细胞，但缺乏黑素细胞。免疫荧光技术显示，突变体鞋底表皮层中存在Ia阳性细胞（可能是朗格汉斯细胞），这些细胞对二硝基氯苯（DNCB）也产生了接触敏感性。hrs可能是一个有用的实验模型，用于研究过敏性和非过敏性皮炎，需要肉眼观察和皱纹皮肤。
Histological and immunological examinations were performed on the skin of a newly established strain of hairless rat (Hirosaki hairless rat; HHR). The appearance of the mutant rat skin was marked by resembles to human skin with wrinkles and scarce vellus hair. The presence of scattered dilated follicular cysts in the mid‐dermis was the most predominant microscopic change. Electron microscopically, some of the basal cells contained many oval organelles in the cytoplasm, although their role was not clear. Langerhans cells were observed, but melanocytes were lacking in the epidermis. Immunofluorescence technique demonstrated Ia‐positive cells (presumably Langerhans cells) in epidermal sheets from the soles of the mutants, which also developed contact sensitivity to dinitrochlorobenzene (DNCB). HHRs may be a useful experimental model for studies of allergic as well as nonallergic dermatitis requiring gross observation and wrinkled skin.