Mechanisms of iron loading and toxicity
Mechanisms of iron loading and toxicity
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DOI：
10.1002/ajh.21075
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发表时间：
2007-12-01
影响因子：
12.8
通讯作者：
Anderson, Gregory J.
中科院分区：
文献类型：
--
作者：
Anderson, Gregory J.
正常的铁稳态是一个精细平衡的系统，反映了铁的吸收，损失和利用。身体没有主动排泄铁的机制，因此身体铁水平控制在小肠吸收点。这种平衡的紊乱，例如导致吸收增强的那些，可能具有显著的临床后果。持续过量的铁摄取之后是各种组织中的铁沉积，最终导致组织损伤，并可能导致终末器官衰竭。在这篇评论中，目前的概念在正常铁稳态，铁负荷进行了解释。临床结果以及初级和二级铁负荷之间的差异也进行了审查，并讨论了一些未来的研究重点。
Normal iron homeostasis is a finely balanced system that reflects iron absorption, loss and utilization. The body has no mechanism for the active excretion of iron, so body iron levels are controlled at the point of absorption in the small intestine. Disturbances in this equilibrium, such as those leading to enhanced absorption, can have significant clinical consequences. Continued excessive iron uptake is followed by iron deposition in various tissues, ultimately leading to tissue damage, and possibly end-organ failure. In this review, current concepts in normal iron homeostasis, and iron loading are explained. The clinical consequences as well as the differences between primary and secondary iron loading are also reviewed, and some future research priorities are discussed.