Assessment of wave propagation on surfaces of crystalline lens with phase sensitive optical coherence tomography
Assessment of wave propagation on surfaces of crystalline lens with phase sensitive optical coherence tomography
复制标题
DOI：
10.1002/lapl.201010102
复制
发表时间：
2011-02-01
影响因子：
1.7
通讯作者：
Larin, K. V.
中科院分区：
文献类型：
--
作者：
Manapuram, R. K.;Baranov, S. A.;Larin, K. V.
我们提出了一种基于相敏扫频源光学相干断层扫描（PhS-SSOCT）模式的实时技术，用于对小鼠晶状体表面产生的非常小的光路长度变化进行无创量化。亚微米机械波在晶状体表面的传播是由周期性机械刺激引起的。获得的结果表明，所描述的方法能够检测晶状体表面振幅小至 30 纳米的微小阻尼振动，因此，PhS-SSOCT 可用于以高精度和高灵敏度评估晶状体的生物力学特性。
We propose a real-time technique based on phase-sensitive swept source optical coherence tomography (PhS-SSOCT) modality for noninvasive quantification of very small optical path length changes produced on the surface of a mouse crystalline lens. Propagation of submicron mechanical waves on the surface of the lens was induced by periodic mechanical stimulation. Obtained results demonstrate that the described method is capable of detecting minute damped vibrations with amplitudes as small as 30 nanometers on the lens surface and hence, PhS-SSOCT could be potentially used to assess biomechanical properties of a crystalline lens with high accuracy and sensitivity.