Ischemia-modified albumin, a predictive marker of major adverse cardiovascular events in continuous ambulatory peritoneal dialysis patients.
Ischemia-modified albumin, a predictive marker of major adverse cardiovascular events in continuous ambulatory peritoneal dialysis patients.
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DOI：
10.1016/j.clinbiochem.2013.06.013
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发表时间：
2013-10
影响因子：
2.8
通讯作者：
Xiaoyan Su;Kun Zhang;Fa-liang Guo;Bing Yuan;Cunrui Wang;Long Xiao;Jingfeng Wang;Hui Huang
中科院分区：
文献类型：
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作者：
Xiaoyan Su;Kun Zhang;Fa-liang Guo;Bing Yuan;Cunrui Wang;Long Xiao;Jingfeng Wang;Hui Huang
目的探讨缺血修饰白蛋白（IMA）对持续不卧床腹膜透析（CAPD）患者主要不良心血管事件（MACE）的预测价值。收集人口统计学和临床数据。主要终点是MACE的发生率。ResultsA共有157名参与者，平均年龄为43.64岁，最终完成了这项研究。CAPD组MACE发生率和IMA水平均显著高于健康对照组（P <0.001）。与IMA水平正常的CAPD患者相比，IMA水平高（> 85 kU/L）的CAPD患者非MACE生存率低（P < 0.001），提示IMA水平高的CAPD患者MACE发生率高。此外，高IMA CAPD患者的血清白蛋白（P < 0.001）和血红蛋白（P = 0.018）水平也较低。相关分析显示，血清白蛋白水平是影响IMA的最主要因素（B =-0.967，P < 0.001）。IMA是CAPD患者发生MACE的良好预测指标，对CAPD患者心血管危险分层有重要意义。
ObjectivesThe aim of this study was to evaluate the efficiency of ischemia-modified albumin (IMA) for predicting major adverse cardiovascular events (MACE) in continuous ambulatory peritoneal dialysis (CAPD) patients.Design and methodsA prospective observational study was conducted with 120 CAPD patients and 37 healthy volunteers. Demographic and clinical data were collected. The primary end point is the occurrence of MACE.ResultsA total of 157 participants with a mean age of 43.64 years finally completed this study. The CAPD patients had a significantly high rate of MACE (P = 0.001) and high levels of IMA than healthy controls (P < 0.001). Compared with CAPD patients with normal levels of IMA, the CAPD patients with high levels of IMA (> 85 kU/L) had lower non-MACE survival rate (P < 0.001), which indicated that the high IMA CAPD patients may suffer a high rate of MACE. In addition, the high IMA CAPD patients also had a low level of serum albumin (P < 0.001) and hemoglobin (P = 0.018). The correlation analysis showed that the serum albumin level was the most effective factor influencing IMA (B = − 0.967, P < 0.001).ConclusionsCAPD patients with high levels of IMA had a high incidence rate of MACE. IMA was a good predictive marker of MACE and might be important in cardiovascular risk stratification of CAPD patients.