Syntheses and evaluation of new acridone derivatives for selective binding of oncogene c-myc promoter i-motifs in gene transcriptional regulation
Syntheses and evaluation of new acridone derivatives for selective binding of oncogene c-myc promoter i-motifs in gene transcriptional regulation
复制标题
新型吖啶酮衍生物的合成和评价，用于在基因转录调控中选择性结合癌基因c-myc启动子i-基序
DOI：
10.1039/c8cc00328a
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发表时间：
2018-02-25
影响因子：
4.9
通讯作者：
Li, Ding
中科院分区：
文献类型：
--
作者：
Shu, Bing;Cao, Jiaojiao;Li, Ding
We synthesized a series of acridone derivatives for specific binding ligands of i-motifs. Subsequent evaluations showed that B19 could selectively bind to and stabilize the c-myc promoter i-motif without significant binding to the G-quadruplex and duplex DNA. This caused down-regulation of c-myc transcription and expression, resulting in tumor cell apoptosis.
