Serum transferrin receptor and its ratio to serum ferritin in the diagnosis of iron deficiency
Serum transferrin receptor and its ratio to serum ferritin in the diagnosis of iron deficiency
复制标题
DOI：
10.1182/blood.v89.3.1052
复制
发表时间：
1997-02-01
期刊：
影响因子：
20.3
通讯作者：
Rajamaki, A
中科院分区：
文献类型：
--
作者：
Punnonen, K;Irjala, K;Rajamaki, A
本研究的目的是评价实验室检查（包括血清转铁蛋白受体（TfR）测量）在诊断铁缺乏中的诊断效率。患者人群包括在图尔库大学医院接受骨髓检查的129名连续贫血患者。在这些患者中，48例患有缺铁性贫血（IDA），64例患有慢性病贫血（ACD），17例患有铁储备耗尽和感染或炎症性疾病（COMBI）。铁储备的耗竭定义为骨髓检查中完全缺乏铁。绝大多数IDA和COMBI患者的血清TfR浓度升高，而ACD患者的水平在早期报告的健康受试者的参考范围内。因此，TfR测量提供了缺铁性贫血的可靠诊断（AUC（ROC）0.98）。血清铁蛋白测定也可区分IDA和ACD患者。然而，最佳的决定限制铁蛋白测量的评价是大大高于传统的参考下限，复杂的解释这个参数。计算TfR/log铁蛋白的比值（TfR-F指数）是结合TfR和铁蛋白结果的一种方法。该比值为鉴定铁储备耗尽的患者提供了一个突出的参数（AUC（ROC）1.00）。在贫血患者中，TfR测量是诊断铁缺乏的一种有价值的非侵入性工具，并提供了一种有吸引力的替代更传统的实验室检测铁储备耗尽。(C)1997年，美国血液学会。
The objective of the study was to evaluate the diagnostic efficiency of laboratory tests, including serum transferrin receptor (TfR) measurements, in the diagnosis of iron depletion. The patient population consisted of 129 consecutive anemic patients at the University Hospital of Turku who were given a bone marrow examination. Of these patients, 48 had iron deficiency anemia (IDA), 64 anemia of chronic disease (ACD), and 17 patients had depleted iron stores and an infectious or an inflammatory condition (COMBI). Depletion of iron stores was defined as a complete absence of stainable iron in the bone marrow examination. Serum TfR concentrations were elevated in the vast majority of the IDA and COMBI patients, while in the ACD patients, the levels were within the reference limits reported earlier for healthy subjects. TfR measurement thus provided a reliable diagnosis of iron deficiency anemia (AUC(ROC) 0.98). Serum ferritin measurement also distinguished between IDA patients and ACD patients. However, the optimal decision limit for evaluation of ferritin measurements was considerably above the conventional lower reference limits, complicating the interpretation of this parameter. Calculation of the ratio TfR/log ferritin (TfR-F Index) is a way of combining TfR and ferritin results. This ratio provided an outstanding parameter for the identification of patients with depleted iron stores (AUC(ROC) 1.00). In anemic patients, TfR measurement is a valuable noninvasive tool for the diagnosis of iron depletion, and offers an attractive alternative to more conventional laboratory tests in the detection of depleted iron stores. (C) 1997 by The American Society of Hematology.