Equivalent levels of mating-induced neural c-fos immunoreactivity in castrated male rats given androgen, estrogen, or no steroid replacement.
Equivalent levels of mating-induced neural c-fos immunoreactivity in castrated male rats given androgen, estrogen, or no steroid replacement.
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在给予雄激素、雌激素或不给予类固醇替代的去势雄性大鼠中，交配诱导的神经 c-fos 免疫反应水平相当。
DOI：
10.1095/biolreprod48.6.1341
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发表时间：
1993
影响因子：
3.6
通讯作者：
Wersinger,SR
中科院分区：
文献类型：
--
作者：
Baum,MJ;Wersinger,SR
用免疫细胞化学方法观察了雄性大鼠在发情期8次与雌性大鼠交配后或单独在竞技场中交配后脑内即刻早期基因c-fos的核蛋白产物（FOS）。交配诱导的FOS免疫反应（IR）神经元的数量在内侧视前区（mPOA），床核的终纹（BNST），和内侧杏仁核组的男性，性腺完整或已被阉割，并与丙酸睾酮，丙酸二氢睾酮，苯甲酸雌二醇（EB），或石油车辆治疗7天。在接受EB或油溶剂但在处死前未与雌性配对的其他去势雄性动物组中，在这些脑区中观察到等同的低数量FOS-IR神经元。循环中的性类固醇激素对交配诱导的c-fosgene表达的刺激作用很小，即使在已知含有高水平雄激素和雌激素受体的脑区也是如此。
The nuclear protein product (FOS) of the immediate-early gene, c-fos, was visualized immunocytochemically in the brains of male rats after they either achieved 8 intromissions with an estrous female or were left alone in a test arena. Mating induced equivalent increments in the number of FOS immunoreactive (IR) neurons present in the medial preoptic area (mPOA), the bed nucleus of the stria terminalis (BNST), and the medial amygdala in groups of males that were gonadally intact or had been castrated and treated for 7 days with either testosterone propionate, dihydrotestosterone propionate, estradiol benzoate (EB), or oil vehicle. Equivalent, low numbers of FOS-IR neurons were seen in these brain regions in additional groups of castrated males that received either EB or oil vehicle but were not paired with a female before being killed. Circulating sex steroids apparently contribute little to the mating-induced stimulation of c-fosgene expression, even in brain regions known to contain high levels of androgen and estrogen receptor.