CODON USAGE AND INTRAGENIC POSITION
CODON USAGE AND INTRAGENIC POSITION
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DOI：
10.1016/s0022-5193(88)80024-9
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发表时间：
1988-07-08
影响因子：
2
通讯作者：
BULMER, M
中科院分区：
文献类型：
--
作者：
BULMER, M
关于大肠杆菌中密码子使用偏向的数据被重新检查与基因内位置有关。与基因的其余部分相比，这种偏向在接近基因开始时没有那么极端，特别是在高表达的基因中。这与之前的发现相反，即密码子使用偏向随着弱表达基因的位置呈线性下降，而在高表达基因的偏向几乎没有变化。正如早先提出的那样，这种影响并不局限于编码带有前导肽的蛋白质的基因(Burns和Beacham，1985)。有一些证据表明，在酵母中也有类似但较小的影响。
Data on codon usage bias in Escherichia coli are re-examined with respect to intragenic position. The bias is less extreme near the beginning than in the rest of the gene, particularly in highly expressed genes. This is contrary to the previous finding that there is a linear decline in codon usage bias with position along weakly expressed genes but little or no change in bias along highly expressed genes. The effect is not confined to genes coding for proteins with leader peptides, as suggested earlier (Burns and Beacham, 1985). There is some evidence of a similar but smaller effect in yeast.