A Phase Model of Temperature-Dependent Mammalian Cold Receptors

A Phase Model of Temperature-Dependent Mammalian Cold Receptors
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温度依赖性哺乳动物冷感受器的相模型

DOI:
10.1162/089976600300015510
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发表时间:
2000
期刊:
影响因子:
2.9
通讯作者:
A. Longtin
A. Longtin
中科院分区:
计算机科学4区
文献类型:
--
作者:
P. Roper;P. Bressloff;A. Longtin

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我们提出了一个易于处理的随机相位模型的温度敏感性的哺乳动物冷受体。使用简单的线性依赖的幅度,频率和温度上的偏差,该模型再现实验观察到的爆裂,跳动,和随机锁相点火模式之间的过渡。我们分析了模型的确定性限制和预测,使用斯特拉特地图,在给定的温度下,每次爆发的尖峰数量。噪声的包含产生了一个可变数量的尖峰每个突发,也扩展了神经元的动态范围,这两者都是分析的斯特拉特地图。我们的分析可以很容易地应用到其他受体,显示各种突发模式的温度变化。
We present a tractable stochastic phase model of the temperature sensitivity of a mammalian cold receptor. Using simple linear dependencies of the amplitude, frequency, and bias on temperature, the model reproduces the experimentally observed transitions between bursting, beating, and stochastically phase-locked firing patterns. We analyze the model in the deterministic limit and predict, using a Strutt map, the number of spikes per burst for a given temperature. The inclusion of noise produces a variable number of spikes per burst and also extends the dynamic range of the neuron, both of which are analyzed in terms of the Strutt map. Our analysis can be readily applied to other receptors that display various bursting patterns following temperature changes.
DOI: 10.1152/jn.1991.66.6.2107
发表时间: 1991-12-01
影响因子: 2.5
作者:
CANAVIER, CC;CLARK, JW;BYRNE, JH
通讯作者: BYRNE, JH