Myenteric denervation reduces the incidence of gastric tumors in rats
Myenteric denervation reduces the incidence of gastric tumors in rats
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DOI：
10.1016/s0304-3835(02)00584-0
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发表时间：
2003-02-10
期刊：
影响因子：
9.7
通讯作者：
Garcia, SB
中科院分区：
文献类型：
--
作者：
Polli-Lopes, AC;Zucoloto, S;Garcia, SB
用苯扎氯铵（BAC）化学性切断大鼠胃神经后，观察了去肌间神经对N-甲基-N '-硝基-N-亚硝基胍（MNNG）诱发胃肿瘤发生的影响。评估了三组：对照组、去神经组和去神经伴幽门成形术组。随机饲养的雄性Wistar大鼠饮用MNNG水（100 mg/l）28周。处死动物后，取出胃进行形态学研究。BAC可减少肌间神经元数量，增加胃粘膜面积，减少腺癌数量和大小。当去神经与幽门成形术相关时，这种下降更明显。这些结果表明，肌间去神经减少实验诱导的胃肿瘤的发病率。(C)2002爱思唯尔科学爱尔兰有限公司保留所有权利。
The influence of myenteric denervation on the development of gastric tumors induced by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) was studied after chemical denervation of the rat stomach with benzalkonium chloride (BAC). Three groups were evaluated: control, denervated and denervated with pyloroplasty. Random bred male Wistar rats were given MNNG in drinking water (100 mg/l) for 28 weeks. After the sacrifice of animals, the stomachs were removed for morphological study. BAC reduced myenteric neurons number, increased the gastric mucosa area and decreased the adenocarcinomas number and size. This decrease was more evident when denervation was associated with pyloroplasty. These results indicate that myenteric denervation reduces the incidence of experimentally induced gastric tumors. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.