Microdose Gentamicin Administration via the Round Window Microcatheter
Microdose Gentamicin Administration via the Round Window Microcatheter
复制标题
通过圆窗微导管进行微剂量庆大霉素给药
DOI：
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发表时间：
2001
影响因子：
5.2
通讯作者：
D. Wester
中科院分区：
文献类型：
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作者：
M. Hoffer;R. Kopke;P. Weisskopf;K. Gottshall;Keith A. Allen;D. Wester
翻译后摘要：transstympanic庆大霉素是越来越受欢迎的梅尼埃病的治疗。在本报告中，我们检查了通过圆窗微导管使用微剂量庆大霉素治疗梅尼埃病的经验。1997年7月至2000年8月期间，36例患者通过圆窗微导管接受庆大霉素给药治疗。所有患者均接受了10天的连续治疗，总剂量为2.4-3.75 mg庆大霉素（10 mg/ml）。所有患者均接受了广泛的治疗前、治疗中和治疗后听觉和前庭测试。本组89%的患者眩晕消失，60%以上的患者耳鸣和血压明显减轻。只有一名患者遭受了严重的听力损失，最重要的是，在所有患者中，除了一名患者外，前庭功能在治疗后得到改善或正常化。圆窗微导管给药微剂量庆大霉素是治疗梅尼埃病的一种令人兴奋的新疗法。初步结果表明，大多数患者的眩晕可以得到控制，而耳蜗或前庭功能不会显著降低。这些结果表明，这种疗法可能在非毛细胞部位起作用。我们的研究结果进行了比较，研究transstympanic注射发表的文献。此外，还研究了支持这种治疗的基础科学。
Abstract: Transtympanic gentamicin is becoming increasingly popular in the treatment of Meniere's disease. In this report we examine our experience with the use of microdose gentamicin via the Round Window Microcatheter for the treatment of Meniere's disease. Thirty‐six patients were treated with gentamicin administration via the Round Window Microcatheter between July 1997 and August 2000. The patients all underwent 10 days of continuous treatment with a total dose of 2.4–3.75 mg of gentamicin (10 mg/ml). All patients had extensive pre‐, intra‐, and post‐therapy auditory and vestibular testing. In this group, vertigo was eliminated in 89% of the patients, and tinnitus and pressure were significantly reduced in over 60% of the patients. Only one patient suffered a significant hearing loss and, most importantly, in all but one patient vestibular function was improved or normalized after treatment. Round Window Microcatheter‐administered microdose gentamicin is an exciting new treatment for Meniere's disease. Preliminary results indicate that vertigo can be controlled without a significant reduction in cochlear or vestibular function in most patients. These results suggest that this therapy may be acting at a non‐hair cell site. Our results are compared to the published literature examining transtympanic injection. In addition, the underlying science supporting this type of treatment is examined.