REGULATION OF SERUM AMYLOID A-GENE EXPRESSION IN SYRIAN-HAMSTERS BY CYTOKINES
REGULATION OF SERUM AMYLOID A-GENE EXPRESSION IN SYRIAN-HAMSTERS BY CYTOKINES
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DOI：
10.1007/bf00917355
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发表时间：
1991-10-01
期刊：
影响因子：
5.1
通讯作者：
JESTUS, JJ
中科院分区：
文献类型：
--
作者：
DOWTON, SB;PETERS, CN;JESTUS, JJ
淀粉样蛋白A（AA）蛋白来源于血清淀粉样蛋白A（SAA），并在反应性淀粉样变性（一种在金黄色叙利亚仓鼠中自发发生的疾病）中沉积为β-折叠片原纤维。 前体SAA是包括仓鼠在内的许多物种的急性期反应物，在本报告中，我们已经定义了各种细胞因子给药后SAA mRNA在仓鼠中积累的体内动力学和剂量反应。 当白细胞介素-1、白细胞介素-6和肿瘤坏死因子的剂量增加时，肝脏SAA mRNA水平升高。 应用剂量的增加范围为白细胞介素-6的2.5倍至白细胞介素-1的10倍。 SAA transcipt水平最高8小时后，管理的白细胞介素-6或肿瘤坏死因子，而SAA特异性mRNA的最大量被发现后24小时管理的白细胞介素-1。
Amyloid A (AA) protein is derived from serum amyloid A (SAA) and deposited as beta-pleated sheet fibrils in reactive amyloidosis, a disease that occurs spontaneously in golden Syrian hamsters. The precursor SAA is an acute-phase reactant in many species including hamsters, and in this report we have defined the in vivo kinetic and dosage responses for SAA mRNA accumulation in hamsters following administration of various cytokines. Elevations in levels of hepatic SAA mRNA were documented when the doses of interleukin-1, interleukin-6, and tumor necrosis factor were increased. The increase in dosages applied ranged from 2 1/2-fold for interleukin-6 to 10-fold for interleukin-1. SAA transcipt levels were highest 8 h following administration of interleukin-6 or tumor necrosis factor, whereas maximal amounts of SAA-specific mRNA were found 24 h after administration of interleukin-1.