A facilely synthesized amino-functionalized metal-organic framework for highly specific and efficient enrichment of glycopeptides

A facilely synthesized amino-functionalized metal-organic framework for highly specific and efficient enrichment of glycopeptides
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一种易于合成的氨基功能化金属有机框架,用于高度特异性和高效富集糖肽

DOI:
10.1039/c4cc05179c
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发表时间:
2014-01-01
影响因子:
4.9
通讯作者:
Zhang, Xin-Xiang
Zhang, Xin-Xiang
中科院分区:
化学2区
文献类型:
--
作者:
Zhang, Yi-Wei;Li, Ze;Zhang, Xin-Xiang

文献摘要

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首次将一种合成简便的氨基功能化金属有机骨架(MOF)MIL-101(Cr)-NH 2应用于基于亲水相互作用的高度特异性糖肽富集。该材料具有MOF的特殊性质,对糖蛋白标准样品和复杂生物样品均具有良好的选择性和灵敏度。
A facilely synthesized amino-functionalized metal-organic framework (MOF) MIL-101(Cr)-NH2 was first applied for highly specific glycopeptide enrichment based on the hydrophilic interactions. With the special characteristics of the MOF, the material performed well in selectivity and sensitivity for both standard glycoprotein samples and complex biological samples.