Gender-related differences in polyamine oxidase activity in rat tissues
Gender-related differences in polyamine oxidase activity in rat tissues
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DOI：
10.1007/bf01361877
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发表时间：
1999-01-01
期刊：
影响因子：
3.5
通讯作者：
Pirona, L
中科院分区：
文献类型：
--
作者：
Ferioli, ME;Pinotti, O;Pirona, L
经常观察到对某些治疗的反应，多胺及其相关酶的水平发生变化，这些变化对男性和女性的影响不同。通过测量多胺氧化酶（脊椎动物组织中普遍存在的酶）的活性，研究了大鼠中多胺氧化存在性别相关差异的可能性，该酶将精胺转化为亚精胺，将亚精胺转化为腐胺。该研究对两性幼鼠的胸腺、脾脏、肾脏和肝脏进行了研究，雌性大鼠在所有组织中均表现出比雄性大鼠更低的多胺氧化酶活性。我们还发现雌性大鼠胸腺和肝脏中的亚精胺乙酰化值高于雄性大鼠。由于这些与性别相关的差异，雌性大鼠的亚精胺 N-乙酰转移酶/多胺氧化酶比率高于雄性大鼠。第二个与性别相关的差异是女性的亚精胺/精胺比率高于男性，唯一的例外是胸腺。这些基础差异可能解释了对某些治疗（包括药物或激素）的多胺代谢酶活性的性别相关差异。
Variations in level of polyamines and their related enzymes are frequently observed in response to some treatments which affect in a different way male and female. The possibility of a gender-related difference in the oxidation of polyamines was investigated in rats by measuring the activity of polyamine oxidase, a ubiquitous enzyme of vertebrate tissues, which transforms spermine into spermidine and spermidine into putrescine. The study was carried out on thymus, spleen, kidney and liver of young rats of both sexes, and female rats showed a lower polyamine oxidase activity than male rats in all the tissues. We also found higher values of spermidine acetylation in female than male rats in thymus and liver. Owing to these gender-related differences, a higher spermidine N-acetyltransferase/polyamine oxidase ratio was found in female than in male rats. A second gender-related difference was a higher spermidine/spermine ratio in female than in male, the only exception being the thymus. These basal differences possibly account for the gender-related differences of polyamine metabolic enzyme activities in response to some treatments, including drugs or hormones.