Compensatory recruitment after sleep deprivation and the relationship with performance
Compensatory recruitment after sleep deprivation and the relationship with performance
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DOI：
10.1016/j.pscychresns.2005.06.007
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发表时间：
2005-12-30
影响因子：
2.3
通讯作者：
Brown, GG
中科院分区：
文献类型：
--
作者：
Drummond, SPA;Meloy, MJ;Brown, GG
本研究考察了完全睡眠剥夺(TSD)对具有两个词汇难度水平的词汇学习任务的大脑反应的影响。对32例受试者在正常睡眠后和TSD后36h进行功能磁共振成像(FMRI)检查。大脑对简单单词的反应在两个晚上都是相同的，但与正常夜间睡眠(正常)相比，TSD后的几个大脑区域对难单词的激活程度更高。这些区域包括双侧额下回、双侧背外侧前额叶和双侧顶下叶。在TSD后，对难记单词的更好的自由回忆表现与左顶下叶、顶上叶和左额下回的大脑反应增加有关。回忆与右额下回的激活呈负相关。总体而言，这些发现支持补偿性招募假说的预测，即任务需求影响在TSD后的任务表现期间大脑激活增加的可能性和位置，并通过确定起作用的特定任务需求来完善这一假说。表现关系表明，增加激活可能是有益的(补偿)，也可能是对任务表现的干扰，这取决于涉及的大脑区域。(C)2005爱思唯尔爱尔兰有限公司。保留所有权利。
This study examined the effects of total sleep deprivation (TSD) on cerebral responses to a verbal learning task with two levels of word difficulty. A total of 32 subjects were studied with functional magnetic resonance imaging (FMRI) after normal sleep and following 36 h of TSD. Cerebral responses to EASY words were identical on both nights, but several brain regions showed increased activation to HARD words following TSD compared with following a normal night of sleep (NORM). These regions included bilateral inferior frontal gyrus, bilateral dorsolateral prefrontal cortex, and bilateral inferior parietal lobe. Better free recall performance on the HARD words after TSD was related to increased cerebral responses within the left inferior and superior parietal lobes and left inferior frontal gyrus. Recall was negatively related to activation within the right inferior frontal gyrus. Overall, the findings support the predictions of the compensatory recruitment hypothesis that task demands influence both the likelihood and location of increased cerebral activation during task performance following TSD, and refine that hypothesis by identifying a specific task demand that plays a role. The performance relationships suggest increased activation may be both beneficial (compensatory) and interfere with task performance, depending on the brain regions involved. (c) 2005 Elsevier Ireland Ltd. All rights reserved.