Cholesterol, high density lipoprotein cholesterol and triglycerides during puberty: the Oslo Youth Study.
Cholesterol, high density lipoprotein cholesterol and triglycerides during puberty: the Oslo Youth Study.
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青春期胆固醇、高密度脂蛋白胆固醇和甘油三酯：奥斯陆青年研究。
DOI：
10.1093/oxfordjournals.aje.a114158
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发表时间：
1985
影响因子：
5
通讯作者：
Vellar,OD
中科院分区：
文献类型：
--
作者：
Tell,GS;Mittelmark,MB;Vellar,OD
对挪威920名10至16岁的青少年进行了血清总胆固醇、高密度脂蛋白（HDL）胆固醇和空腹甘油三酯（根据体重指数调整，wt/ht2）与青春期发育阶段的关系研究。对于13岁和14岁的孩子，坦纳成熟度指数的所有五个阶段都得到了体现。在整个人群中，血清总胆固醇与性成熟阶段相关的下降幅度大于与实际年龄相关的下降幅度。女性高密度脂蛋白胆固醇和甘油三酯与年龄相关显著升高；当与成熟度指数相关时，没有发现这一点。与性成熟阶段相比，甘油三酯与男性年龄相关的增加幅度更大。在13岁和14岁的男性中，最成熟的人的总胆固醇值明显低于最不成熟的人。对于12岁的男性，高密度脂蛋白胆固醇随着性成熟的增加而显著下降。在女性中，越成熟的12岁儿童的总胆固醇值明显低于不成熟的12岁儿童。早熟的13岁、14岁和15-16岁的孩子的高密度脂蛋白胆固醇水平比晚熟的孩子低。这些发现表明，年龄可能是青少年发育的一个较差的指标，生理发育年龄的测量应该包括在青少年血脂的流行病学研究中。
The relationships of serum total cholesterol, high density lipoprotein (HDL) cholesterol and fasting triglycerides (adjusted for body mass index, wt/ht2) with stages of pubertal development were examined in a Norwegian population of 920 adolescents, aged 10 to 16 years. For 13-and 14-year-olds, all five stages of Tanner's maturity index were represented. For the whole population, total serum cholesterol showed a larger decrease when related to sexual maturity stage than to chronologic age. For females, HDL cholesterol and triglycerides increased significantly when related to age in years; this was not found when related to the maturity index. Triglycerides showed a larger increase when related to chronologic age in males as compared with sexual maturity stage. Both among 13-and 14-year-old males, the most mature had significantly lower values for total cholesterol than the least mature. For 12-year-old males, HDL cholesterol decreased significantly with increasing sexual maturation. Among females, the more mature 12-year-olds had significantly lower values for total cholesterol compared with the less mature. Early maturing 13-, 14- and 15-16-year-olds had lower levels of HDL cholesterol compared with late maturers. These findings suggest that age in years may be a poor index of development in adolescents and that a measure of physiologic developmental age should be included in epidemiologic studies of serum lipids among adolescents.