Sodium butyrate modulates a methamphetamine-induced conditioned place preference
Sodium butyrate modulates a methamphetamine-induced conditioned place preference
复制标题
丁酸钠调节甲基苯丙胺诱导的条件性位置偏好
DOI：
10.1002/jnr.23835
复制
发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Teng Chen
中科院分区：
文献类型：
--
作者：
Jie Zhu;Na Zhao Na;Yanjiong Chen;Li Zhu;Qing Zhong;Jian Liu;Teng Chen
以前的研究表明，组蛋白乙酰化调控相关基因的转录表达，从而有助于成瘾行为的持续和神经可塑性。然而，组蛋白乙酰化在甲基苯丙胺(METH)诱导的条件性位置偏爱(CPP)不同阶段的作用仍不清楚。本研究检测了组蛋白脱乙酰酶(HDACs)抑制剂丁酸钠(NAB)对冰毒诱导的小鼠CPP的获得、消退和恢复的影响。结果表明，1 mg/kg冰毒作用于小鼠4次条件反射后，可诱发小鼠持续持续的条件反射。冰毒诱导的CPP在三次消退训练后被消除，并可在恢复测试当天被相同剂量的冰毒(1 mg/kg)触发。同时，NaB(4 0 0 mg/kg)本身对小鼠的自然偏爱没有影响，但在条件化和消退期注射NaB分别促进了冰毒诱导的CPP的获得和消退。此外，虽然在触发CPP恢复之前没有观察到单次注射NAB的效果，但在消退阶段重复注射NAB完全阻止了冰毒诱导的CPP的恢复。综上所述，我们的结果提示，组蛋白乙酰化在调节冰毒诱导的CPP的不同阶段具有特异性，在消退期处理NAB不仅对消除已经建立的CPP产生有利的作用，而且还能阻止冰毒诱导的CPP的恢复。©2016 Wiley期刊，Inc.
Previous studies demonstrated that histone acetylation modulated the transcription of associated gene expression and thus contributed to the persistence of addictive behaviors and neuroplasticity. Nonetheless, the roles of histone acetylation in distinct phases of methamphetamine (METH)‐induced conditioned place preference (CPP) remain unclear. The current study examines the effects of the histone deacetylases (HDACs) inhibitor sodium butyrate (NaB) on the acquisition, extinction, and reinstatement of METH‐induced CPP in mice. Our results showed that 1 mg/kg METH induced CPP in mice after four conditioning sessions. METH‐induced CPP was extinguished after three extinction training sessions and could be triggered by the same dose (1 mg/kg) of METH on the reinstatement test day. Meanwhile, NaB (400 mg/kg) per se had no effect on the natural preference of mice, but injections of NaB during the conditioning and extinction phases facilitated the acquisition and extinction of METH‐induced CPP, respectively. Additionally, although the effect of a single NaB injection prior to the trigger of CPP reinstatement was not observed, repeated NaB injections during the extinction phase totally blocked the reinstatement of METH‐induced CPP. Taken together, our results suggested a specific effect of histone acetylation on modulating distinct phases of METH‐induced CPP and that treatment of NaB during the extinction phase not only produced beneficial effects on eliminating already established CPP but also blocked the reinstatement of METH‐induced CPP. © 2016 Wiley Periodicals, Inc.