Dietary oligofructose lessens hepatic steatosis, but does not prevent hypertriglyceridemia in obese Zucker rats
Dietary oligofructose lessens hepatic steatosis, but does not prevent hypertriglyceridemia in obese Zucker rats
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DOI：
10.1093/jn/130.5.1314
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发表时间：
2000-05-01
影响因子：
4.2
通讯作者：
Delzenne, NM
中科院分区：
文献类型：
--
作者：
Daubioul, CA;Taper, HS;Delzenne, NM
我们研究了低聚果糖（OFS），一种不易消化的果聚糖，对肥胖fa/fa Zucker大鼠脂质代谢的影响。在饮食中添加10 g/100 g OFS减缓了体重的增加，但治疗7周后未改变血清甘油三酯或葡萄糖浓度。然而，口服2 g葡萄糖和5 g玉米油/kg体重的负荷增加OFS喂养大鼠的血吸虫病比对照组大鼠。10周后，PFS使肝脏甘油三酯浓度相对于对照组降低57%。组织学分析证实了不太严重的脂肪变性。在参与脂肪酸合成和酯化的关键酶中，只有苹果酸酶活性在OFS喂养的大鼠中显著低于对照组。OFS喂养大鼠的附睾脂肪量显著降低。总之，膳食中富含OFS可以抵消肥胖Zucker大鼠的脂肪量发展和肝脏脂肪变性。未来的研究将旨在阐明肥胖动物的饮食OFS对餐后高脂血症的影响，这是一个重要的变量与人类动脉粥样硬化的发展，并分析生化机制的“保肝”作用的OFS。
We studied the influence of oligofructose (OFS), a nondigestible fructan, on lipid metabolism in obese fa/fa Zucker rats. The addition of 10 g/100 g OFS to the diet slowed the increase in body weight without modifying serum triglycerides or glucose concentrations after 7 wk of treatment. However, an oral load of 2 g glucose and 5 g corn oil/kg body weight increased triglyceridemia more in OFS-fed rats than in control rats. After 10 wk,PFS decreased the hepatic concentration of triglycerides 57% relative to controls. The less severe steatosis was confirmed by histologic analysis. Among the key enzymes involved in fatty acid synthesis and esterification, only malic enzyme activity was significantly lower in OFS-fed rats than in controls. The epididymal fat mass was significantly lower in OFS-fed rats. In conclusion, dietary enrichment with OFS can counteract both the fat mass development and the hepatic steatosis that occur in obese Zucker rats. Future studies will be designed to clarify in obese animals the influence of dietary OFS on postprandial triglyceridemia, which is an important variable associated with the development of atherosclerosis in humans, and to analyze the biochemical mechanism underlying the "hepatoprotective" effect of OFS.