Tumor-derived lymphangiogenic factors and lymphatic metastasis
Tumor-derived lymphangiogenic factors and lymphatic metastasis
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DOI：
10.1016/j.biopha.2007.08.009
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发表时间：
2007-10-01
影响因子：
7.5
通讯作者：
Zhong, Weide
中科院分区：
文献类型：
--
作者：
Cao, Yihai;Zhong, Weide
淋巴内皮细胞（LECs）最初是从静脉内皮细胞分化出来的，其表达了几种特异性的制造蛋白，使其与血管区分开来。淋巴管生成是一个复杂的新生淋巴管萌芽过程，受多种直接of和间接生长因子的调控。血管内皮生长因子- c （VEGF-C）是最有效和选择性的淋巴管生成因子，在胚胎发育过程中第一淋巴管的建立和淋巴转移中起着至关重要的作用。除了VEGF-C，最近的研究表明，一系列已知的肿瘤产生的血管生成因子也刺激淋巴管生成，表明这一过程的复杂和严格的调控。这些肿瘤源性淋巴管生成因子可能单独或共同促进淋巴转移。了解淋巴管生成的调节机制对于开发淋巴管生成拮抗剂至关重要，这些拮抗剂可能用于治疗淋巴转移的干预。(C) 2007 Elsevier Masson SAS。版权所有。
Lymphatic endothelial cells (LECs) originally differentiated from venous endothelial cells express several specific makers that distinguish them from the blood vessels. Lymphangiogenesis, a complex process of sprouting of new lymphatic vessels, is regulated by multiple direct OF and indirect growth factors. Vascular endothelial growth factor-C (VEGF-C) is the most potent and selective lymphangiogenic factor that plays a crucial role in the establishment of the first lymphatic vessel during embryonic development and in mediating lymphatic metastasis. In addition to VEGF-C, recent studies show that a range of known tumor-produced angiogenic factors also stimulates lymphangiogenesis, suggesting complex and tight regulations of this process. These tumor-derived lymphangiogenic factors may either alone or jointly promote lymphatic metastasis. Understanding regulatory mechanisms of lymphangiogenesis is pivotal for development of lymphangiogenesis antagonists that might therapeutically be used for intervention of lymphatic metastasis. (C) 2007 Elsevier Masson SAS. All rights reserved.