Hemophagocytic macrophages constitute a major compartment of heme oxygenase expression in sepsis.
Hemophagocytic macrophages constitute a major compartment of heme oxygenase expression in sepsis.
复制标题
嗜血型巨噬细胞构成败血症中血红素氧酶表达的主要区室。
DOI：
10.1111/j.1600-0609.2006.00730.x
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发表时间：
2006-11
影响因子：
3.1
通讯作者：
Kurrer, Michael O
中科院分区：
文献类型：
--
作者：
Schaer, Dominik J;Schaer, Christian A;Schoedon, Gabriele;Imhof, Alexander;Kurrer, Michael O
Schaer DJ、Schaer CA、Schoedon G、Imhof A、Kurrer MO。噬血细胞巨噬细胞构成脓毒症中血红素加氧酶表达的主要区室。目的：巨噬细胞活化不受控制并伴有噬血细胞作用是噬血细胞综合征 (HPS) 的一个显着特征。我们检查了脓毒症期间是否也发生骨髓和肝脏的淋巴组织细胞浸润以及噬血细胞/红细胞吞噬作用，以及该过程是否可以解释脓毒症期间观察到的抗炎血红素加氧酶（HO-1）产物的产生增加。方法：检测 28 名脓毒症患者和 8 名对照患者的死后骨髓样本中的噬血细胞作用和 CD163、HO-1、铁蛋白以及 CD8 和颗粒酶 B 的表达。结果：非脓毒症患者样本与致命性脓毒症患者样本的比较显示，后者表现出致密的淋巴细胞组织细胞骨髓浸润，其中有 CD163+/HO-1+/铁蛋白+巨噬细胞以及 CD8+ 和粒酶 B+ T 细胞。在脓毒症患者中，噬血作用和对红系细胞的显着吞噬作用很明显，这意味着该过程可能刺激巨噬细胞 HO-1 表达上调。结论：淋巴组织细胞活化伴噬血作用是 HPS 和脓毒症的共同病理生理机制。此外，噬血作用与 HO-1 表达增加的关联可能表明这种看似徒劳的过程作为炎症负调节剂的新作用。
Schaer DJ, Schaer CA, Schoedon G, Imhof A, Kurrer MO. Hemophagocytic macrophages constitute a major compartment of heme oxygenase expression in sepsis. Objectives: Uncontrolled macrophage activation with hemophagocytosis is a distinctive feature of hemophagocytic syndromes (HPS). We examined whether lympho-histiocytic infiltration of the bone marrow and liver, as well as hemo-/erythrophagocytosis also occurs during sepsis and whether this process could account for the increased production of anti-inflammatory heme-oxygenase (HO-1) products observed during sepsis. Methods: Hemophagocytosis and expression of CD163, HO-1, ferritin as well as CD8 and granzyme-B were examined in post-mortem bone marrow samples from 28 patients with sepsis and from eight control patients. Results: Comparison of samples from non-septic patients with samples from patients with fatal sepsis revealed that the latter group displayed dense lympho-histiocytic bone marrow infiltration with CD163+/HO-1+/ferritin+ macrophages as well as with CD8+ and granzyme-B+ T-cells. Hemophagocytosis with prominent phagocytosis of erythroid cells was readily apparent in septic patients, implying that this process is a likely stimulus for the up-regulation of macrophage HO-1 expression. Conclusions: Lympho-histiocytic activation with hemophagocytosis is a shared pathophysiologic mechanism in HPS and sepsis. Furthermore, the association of hemophagocytosis with an increase in HO-1 expression may indicate a novel role for this apparently futile process as a negative regulator of inflammation.