Increases in serum unbound free fatty acid levels following coronary angioplasty
Increases in serum unbound free fatty acid levels following coronary angioplasty
复制标题
DOI：
10.1016/s0002-9149(96)00651-0
复制
发表时间：
1996-12-15
影响因子：
2.8
通讯作者：
DeMaria, A
中科院分区：
文献类型：
--
作者：
Kleinfeld, AM;Prothro, D;DeMaria, A
应用荧光探针丙烯酰-肠脂肪酸结合蛋白（ADIFAB）测定了经皮冠状动脉腔内成形术（PTCA）患者血清游离脂肪酸（FFu）水平。这是首次在非生理条件下测量FFA（u）。在这些研究中，在手术前5分钟和手术后30分钟测定了22名患者的FFA（u）水平。所有患者的PTCA后FFA（u）水平均高于PTCA前水平。所有患者的平均PTCA后水平为103 nM，比在健康受试者中观察到的7.5 nM值高约14倍。尽管所有患者在PTCA后FFA（u）水平均升高，但仅在其中11例患者中观察到缺血性ST段改变。有显著ST段改变的患者的平均PTCA后FFA（u）水平（123 nM）显著高于未表现出此类改变的患者（47 nM）。相对于健康受试者，患者人群中术前FFA（u）（22 nM）平均水平升高，这些值与PTCA后水平呈正相关。这些结果表明，血清FFA（u）水平升高反映了血管成形术诱导的缺血，FFA（u）水平可能提供比心电图测量更敏感的缺血测量。此外，由于这些患者中有30%的患者在PTCA后FFA（u）浓度超过了体外细胞功能的改变，因此伴随缺血的血清FFA（u）水平升高可能对心肌功能有害。(C)1996年，Excerpta Medica，Inc.
Serum unbound free fatty acid levels (FFu) were measured in patients undergoing percutaneous transluminal coronary angioplasty (PTCA) using the fluorescent probe acrylodan intestinal fatty acid binding protein (ADIFAB). These ore the first measurements of FFA(u) under nonphysiologic conditions. In these studies, FFA(u) levels were determined in 22 patients 5 minutes before and 30 minutes after the procedure. Post-PTCA FFA(u) levels were higher than pre-PTCA levels in all patients. The average post-PTCA level for all patients was 103 nM, about 14-fold higher than the 7.5 nM value observed in healthy subjects. Although all patients exhibited elevated FFA(u) levels after PTCA, ischemic ST-segment changes were observed in only 11 of these patients. The average post-PTCA FFA(u) levels for patients with significant ST-segment changes (123 nM) were significantly higher than those in patients who did not exhibit such changes (47 nM). Average FFA(u) (22 nM) levels before the procedure were elevated in the patient population relative to healthy subjects and these values correlated positively with post-PTCA levels. These results suggest that increased serum FFA(u) levels reflect angioplasty-induced ischemia and that FFA(u) levels may provide a more sensitive measure of ischemia than electrocardiographic measurements. Moreover, because 30% of these patients had post-PTCA FFA(u) concentrations exceeding those found to alter in vitro cell function, the increased serum FFA(u) levels that accompany ischemia may be deleterious for myocardial function. (C) 1996 by Excerpta Medica, Inc.