Geometric features of pig airways using computed tomography.
Geometric features of pig airways using computed tomography.
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DOI：
10.14814/phy2.12995
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发表时间：
2016-10
影响因子：
2.5
通讯作者：
Gamage PT
中科院分区：
文献类型：
--
作者：
Azad MK;Mansy HA;Gamage PT
在构建气道树的物理模型以及对气道中的流动或声音传播进行数值建模时，需要气道几何形状的准确知识。进行了人体和动物实验来验证这些模型。许多研究记录了人类气道的几何细节。然而，猪气道的几何形状的信息是稀缺的。早期的研究表明，动物气道的形态可能与人类气道的形态显著不同。本研究的目的是利用计算机断层扫描技术测量家猪的气道直径、长度和分叉角度。在这项研究中，六只猪的肺成像，然后分割软件工具被用来提取气道腔的几何形状。从产生的前24代气道的3D模型中测量气道尺寸。结果表明，6只猪的气道大小和形态相似。发现气管直径与典型的人类成年人相当，但其他气道的直径、长度和分支角度与人类明显不同。例如，猪的气道始终具有来自气管的早期分支，该气管为右上肺叶提供营养，并且在主隆突之前。这种分支在人体气道中是不存在的。结果表明，猪气道几何形状可能无法准确地近似于人类气道，这种近似可能会导致猪胸部计算模型中的误差增加。
Accurate knowledge of the airway geometry is needed when constructing physical models of the airway tree and for numerical modeling of flow or sound propagation in the airways. Human and animal experiments are conducted to validate these models. Many studies documented the geometric details of the human airways. However, information about the geometry of pig airways is scarcer. Earlier studies suggested that the morphology of animal airways can be significantly different from that of humans. The objective of this study is to measure the airway diameter, length and bifurcation angles in domestic pigs using computed tomography. In this study, lungs of six pigs were imaged, then segmentation software tools were used to extract the geometry of the airway lumen. The airway dimensions were measured from the resulting 3‐D models for the first 24 airway generations. Results showed that the size and morphology of the airways of the six pigs were similar. The trachea diameters were found to be comparable to the typical human adult, but the diameter, length and branching angles of other airways were noticeably different from that of humans. For example, pig airways consistently had an early branching from the trachea that feeds the top right lung lobe and precedes the main carina. This branch is absent in the human airways. The results suggested that the pig airways geometry may not be accurately approximated by human airways and this approximation may contribute to increasing the errors in computational models of the pig chest.