Common variants near TERC are associated with mean telomere length.
Common variants near TERC are associated with mean telomere length.
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作者：
我们对2，917名受试者的平均白细胞端粒长度进行了全基因组关联分析，并对9，492名受试者进行了随访复制分析，并在3q26上确定了一个包含端粒酶RNA组分TERC的基因座，并有令人信服的关联证据（rs12696304，合并P值3.72×10−14）。rs12696304次要等位基因的每一个拷贝与短于平均端粒长度的1075个碱基对相关，相当于平均端粒长度的103.6岁的年龄相关损耗。
We conducted genome-wide association analyses of mean leukocyte telomere length in 2,917 subjects and follow-up replication analyses in 9,492 and identified a locus on 3q26 encompassing the telomerase RNA component TERC, with compelling evidence for association (rs12696304, combined P value 3.72×10−14). Each copy of the minor allele of rs12696304 was associated with ≈75 base pairs shorter mean telomere length equivalent to ≈3.6 years of age-related attrition of mean telomere length.