SIGNET-RING-CELL CARCINOMA OF THE PROSTATE - ELECTRON-MICROSCOPIC AND IMMUNOHISTOCHEMICAL STUDIES OF 8 CASES
SIGNET-RING-CELL CARCINOMA OF THE PROSTATE - ELECTRON-MICROSCOPIC AND IMMUNOHISTOCHEMICAL STUDIES OF 8 CASES
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DOI：
10.1097/00000478-198806000-00005
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发表时间：
1988-06-01
影响因子：
5.6
通讯作者：
ORDONEZ, NG
中科院分区：
文献类型：
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作者：
RO, JY;ELNAGGAR, A;ORDONEZ, NG
原发性前列腺印戒细胞癌是非常罕见的。我们报告8例前列腺癌含有大量的印戒细胞，其中一人最初提出锁骨上淋巴结转移。患者年龄范围为50 - 80岁（平均67.5岁）。所有患者在活检或手术前均未接受任何形式的治疗。所有患者均表现为晚期疾病（5例C期，3例D期）。所有肿瘤均为低分化腺癌，MD安德森医院系统IV级，Gleason综合评分为9或10。印戒细胞呈中性和酸性粘蛋白阴性，但前列腺特异性抗原和前列腺酸性磷酸酶免疫反应阳性。超微结构上，印戒细胞的外观导致无论是从胞浆内腔或空泡的存在。印戒细胞也出现在转移部位。我们的结论是：（a）前列腺印戒细胞癌是前列腺低分化腺癌的一种变体;（B）当识别出胞浆内粘蛋白阴性的转移性印戒细胞癌时，应考虑前列腺起源，并应进行前列腺特异性抗原和前列腺酸性磷酸酶免疫染色。
Primary signet-ring-cell carcinoma of the prostate is extremely rare. We report eight patients with prostatic adenocarcinomas containing significant numbers of signetring cells, one of whom presented initially with supraclavicular lymph node metastasis. Patient ages ranged from 50 to 80 years (mean, 67.5). None of the patients had received any form of therapy before biopsy or surgery. All patients presented with advanced disease (five with stage C and three with stage D). All tumors were poorly differentiated adenocarcinomas, MD Anderson Hospital system grade IV, Gleason's combined score of 9 or 10. The signet-ring cells were negative for neutral and acid mucins but immunoreactive for prostatic-specific antigen and prostatic acid phosphatase. Ultrastructurally, the signet-ring-cell appearance resulted either from the presence of intracytoplasmic lumina or from vacuoles. Signet-ring cells were also present at the metastatic sites. We conclude that (a) signet-ring-cell carcinoma of the prostate is a variant of poorly differentiated adenocarcinoma of the prostate; and (b) when a metastatic signet-ring-cell carcinoma with negative intracytoplasmic mucin is identified, a prostatic origin should be considered, and prostatic-specific antigen and prostatic acid phosphatase immunostaining should be performed.