Immune checkpoint inhibitor associated myocarditis occurs in both high-grade and low-grade forms
Immune checkpoint inhibitor associated myocarditis occurs in both high-grade and low-grade forms
复制标题
DOI：
10.1038/s41379-019-0363-0
复制
发表时间：
2020-01-01
期刊：
影响因子：
7.5
通讯作者：
Stone, James R.
中科院分区：
文献类型：
--
作者：
Champion, Samantha N.;Stone, James R.
恶性肿瘤的免疫检查点抑制剂治疗与包括心肌炎在内的不良事件相关。目前尚不清楚这种心肌炎是否有不同的病理分级与不同的临床结局相关。采用免疫组织化学方法对10例免疫检查点抑制剂心肌炎患者（9例活检和1例尸检）的心脏组织进行了CD 3、CD 8、CD 68、类胰蛋白酶、PD-L1和C4D的评价。免疫检查点抑制剂心肌炎病例分为高级别（>50 CD 3（+）细胞/hpf）或低级别（
Immune checkpoint inhibitor therapy for malignancy has been associated with adverse events including myocarditis. It has been unclear if there are distinct pathologic grades of this myocarditis that are associated with distinct clinical outcomes. Cardiac tissue from ten patients with immune checkpoint inhibitor myocarditis (nine biopsies and one autopsy) were evaluated using immunohistochemistry for CD3, CD8, CD68, tryptase, PD-L1, and C4D. The immune checkpoint inhibitor myocarditis cases were classified as either high grade (>50 CD3(+) cells/hpf) or low grade (